NDLI: Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

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Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

Content Provider	Scilit
Author	Keymeulen, Bart Candon, Sophie Fafi-Kremer, Samira Ziegler, Anette Leruez-Ville, Marianne Mathieu, Chantal Vandemeulebroucke, Evy Walter, Markus Crenier, Laurent Thervet, Eric Legendre, Christophe Pierard, Denis Hale, Geoff Waldmann, Herman Bach, Jean-François Seigneurin, Jean Marie Pipeleers, Daniel Chatenoud, Lucienne
Copyright Year	2010
Description	Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an EBV-specific T-cell response. The anti-CD3 antibody administration induced short-lasting immunosuppression and minor yet clear-cut signs of T-cell activation that preceded viral reactivation. Early posttransplant monitoring of renal and islet allograft recipients showed that no comparable phenomenon was observed after the administration of full-dose immunosuppressive therapy. This EBV reactivation remains of no apparent clinical concern over the long term and should not preclude further development of therapeutic anti-CD3 antibodies. This phenomenon may also direct new research avenues to understand the still ill-defined nature of stimuli triggering EBV reactivation in vivo.
Related Links	http://www.bloodjournal.org/content/115/6/1145.full.pdf
Ending Page	1155
Page Count	11
Starting Page	1145
DOI	10.1182/blood-2009-02-204875
Journal	Blood
Issue Number	6
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-02-11
Access Restriction	Open
Subject Keyword	Virology Antibody Virus Cd3 Epstein Barr Treatment Ebv Diabetes Immunosuppression Administration Journal: Blood (Vol- 90, Issue- 6)
Content Type	Text
Resource Type	Article

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