NDLI: The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to γδ T-cell cytotoxicity

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The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to γδ T-cell cytotoxicity

Content Provider	Scilit
Author	Lança, Telma Correia, Daniel V. Moita, Catarina F. Raquel, Helena Neves-Costa, Ana Ferreira, Cristina Ramalho, José S. Barata, João T. Moita, Luís F. Gomes, Anita Q. Silva-Santos, Bruno
Copyright Year	2010
Description	On the path to successful immunotherapy of hematopoietic tumors, γδ T cells offer great promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by γδ T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to γδ T cell–mediated cytolysis. Consistent with this, blockade of NKG2D, the receptor for ULBP1 expressed on all Vγ9+ T cells, significantly inhibits lymphoma cell killing. Specific loss-of-function studies demonstrate that the role of ULBP1 is nonredundant, highlighting a thus far unique physiologic relevance for tumor recognition by γδ T cells. Importantly, we observed a very wide spectrum of ULBP1 expression levels in primary biopsies obtained from lymphoma and leukemia patients. We suggest this will impact on the responsiveness to γδ T cell–based immunotherapy, and therefore propose ULBP1 to be used as a leukemia/lymphoma biomarker in upcoming clinical trials.
Related Links	http://www.bloodjournal.org/content/115/12/2407.full.pdf
Ending Page	2411
Page Count	5
Starting Page	2407
DOI	10.1182/blood-2009-08-237123
Journal	Blood
Issue Number	12
Volume Number	115
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-03-25
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Protein Antigen Ulbp1 Hematopoietic Γδ T Cells Immunotherapy Function Lymphoma Nonredundant Journal: Blood (Vol- 121, Issue- 12)
Content Type	Text
Resource Type	Article

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