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Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense
| Content Provider | Scilit |
|---|---|
| Author | Xu, Honglin Chun, Taehoon Choi, Hak-Jong Wang, Bin Wang, Chyung-Ru |
| Copyright Year | 2006 |
| Description | The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formylated bacterial peptides. However, the significance of H2-M3–restricted T cells in host defense against bacteria is unclear. We generated H2-M3–deficient mice to investigate the role of H2-M3 in immunity against Listeria monocytogenes (LM), a model intracellular bacterial pathogen. H2-M3–deficient mice are impaired in early bacterial clearance during primary infection, with diminished LM-specific CD8+ T cell responses and compromised innate immune functions. Although H2-M3–restricted CD8+ T cells constitute a significant proportion of the anti-listerial CD8+ T cell repertoire, the kinetics and magnitude of MHC class Ia–restricted T cell responses are not altered in H2-M3–deficient mice. The fact that MHC class Ia–restricted responses cannot compensate for the H2-M3–mediated immunity suggests a nonredundant role of H2-M3 in the protective immunity against LM. Thus, the early H2-M3–restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system. |
| Related Links | http://jem.rupress.org/content/jem/203/2/449.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118219/pdf http://jem.rupress.org/content/203/2/449.full.pdf |
| Ending Page | 459 |
| Page Count | 11 |
| Starting Page | 449 |
| DOI | 10.1084/jem.20051866 |
| Journal | The Journal of experimental medicine |
| Issue Number | 2 |
| Volume Number | 203 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 2006-02-20 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Innate Immune Deficient Mice H2 M3 Mhc Class Nonredundant Role Journal: The Journal of experimental medicine (Vol- 203, Issue- 2) |
| Content Type | Text |