NDLI: An MHC class Ib–restricted CD8 T cell response confers antiviral immunity

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An MHC class Ib–restricted CD8 T cell response confers antiviral immunity

Content Provider	Scilit
Author	Swanson, Phillip A. Pack, Christopher D. Hadley, Annette Wang, Chyung-Ru Stroynowski, Iwona Jensen, Peter E. Lukacher, Aron E.
Copyright Year	2008
Description	Although immunity against intracellular pathogens is primarily provided by CD8 T lymphocytes that recognize pathogen-derived peptides presented by major histocompatibility complex (MHC) class Ia molecules, MHC class Ib–restricted CD8 T cells have been implicated in antiviral immunity. Using mouse polyoma virus (PyV), we found that MHC class Ia–deficient (Kb−/−Db−/−) mice efficiently control this persistently infecting mouse pathogen. CD8 T cell depletion mitigates clearance of PyV in Kb−/−Db−/− mice. We identified the ligand for PyV-specific CD8 T cells in Kb−/−Db−/− mice as a nonamer peptide from the VP2 capsid protein presented by Q9, a member of the β2 microglobulin–associated Qa-2 family. Using Q9-VP2 tetramers, we monitored delayed but progressive expansion of these antigen-specific CD8αβ T cells in Kb−/−Db−/− mice. Importantly, we demonstrate that Q9-VP2–specific CD8 T cells more effectively clear wild-type PyV than a VP2 epitopenull mutant PyV. Finally, we show that wild-type mice also generate Q9-restricted VP2 epitope–specific CD8 T cells to PyV infection. To our knowledge, this is the first evidence for a defined MHC class Ib–restricted antiviral CD8 T cell response that contributes to host defense. This study motivates efforts to uncover MHC class Ib–restricted CD8 T cell responses in other viral infections, and given the limited polymorphism of MHC class Ib molecules, it raises the possibility of developing peptide-based viral vaccines having broad coverage across MHC haplotypes.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442642/pdf
Ending Page	1657
Page Count	11
Starting Page	1647
DOI	10.1084/jem.20080570
Journal	The Journal of experimental medicine
Issue Number	7
Volume Number	205
Language	English
Publisher	Rockefeller University Press
Publisher Date	2008-06-09
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Protein Virus Antiviral Vaccines Antigen Class Mhc Cd8 T Cell Pyv Journal: The Journal of experimental medicine (Vol- 205, Issue- 7)
Content Type	Text

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