NDLI: The MHC class Ib protein ULBP 1 is a nonredundant determinant of leukemia / lymphoma susceptibility to T-cell cytotoxicity

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The MHC class Ib protein ULBP 1 is a nonredundant determinant of leukemia / lymphoma susceptibility to T-cell cytotoxicity

Content Provider	Semantic Scholar
Author	Lança, Telma Correia, Daniel Moita, Catarina F. Raquel, Helena Neves-Costa, Ana Ferreira, Cristina Ramalho, José S. Barata, Joao T. Moita, Luís Ferreira Gomes, Anita Q. Silva-Santos, Bruno
Copyright Year	2010
Abstract	On the path to successful immunotherapy of hematopoietic tumors, T cells offer great promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide variety of leukemias/ lymphomas. However, the molecular mechanisms underlying lymphoma recognition by T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to T cell–mediated cytolysis. Consistent with this, blockade of NKG2D, the receptor for ULBP1 expressed on all V 9 T cells, significantly inhibits lymphoma cell killing. Specific loss-of-function studies demonstrate that the role of ULBP1 is nonredundant, highlighting a thus far unique physiologic relevance for tumor recognition by T cells. Importantly, we observed a very wide spectrum of ULBP1 expression levels in primary biopsies obtained from lymphoma and leukemia patients. We suggest this will impact on the responsiveness to T cell–based immunotherapy, and therefore propose ULBP1 to be used as a leukemia/lymphoma biomarker in upcoming clinical trials. (Blood. 2010;115:2407-2411)
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/115/12/2407.full.pdf?sso-checked=true
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/early/2010/01/25/blood-2009-08-237123.full.pdf?sso-checked=true
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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