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CD4+CD25+ Treg cells inhibit human memory γδ T cells to produce IFN-γ in response to M tuberculosis antigen ESAT-6
| Content Provider | Scilit |
|---|---|
| Author | Li, Li Wu, Chang-You |
| Copyright Year | 2008 |
| Description | γδ T cells play an important role in innate immunity against infections; however, the regulation of these cells remains largely unknown. In the present study, we show that ESAT-6, an antigen of Mycobacterium tuberculosis, induces IFN-γ secretion by human γδ T cells. In addition, ESAT-6 also induces the activation and proliferation of γδ T cells. Phenotypic analysis indicates that IFN-γ–producing γδ T cells are mainly effector memory cells with the surface phenotype of CD45RA−CD62L−CCR7−. These results were further confirmed by the fact that naive γδ T cells from cord blood did not produce IFN-γ in response to ESAT-6. Further studies indicated that stimulation with ESAT-6 directly induced purified γδ T cells to produce IFN-γ, independent of both antigen-presenting cells and CD4+ T cells. Unexpectedly, depletion of CD4+ T cells markedly enhanced IFN-γ production by γδ T cells, indicating that CD4+ T cells regulate the response of γδ T cells. Importantly, CD4+CD25+ T regulatory (Treg) cells but not CD4+CD25− T cells significantly inhibited IFN-γ production by γδ T cells. Taken together, these data demonstrate for the first time that Treg cells can play an important role in the regulation of immune responses of antigen-specific human memory γδ T cells. |
| Related Links | http://bloodjournal.hematologylibrary.org/content/111/12/5629.full.pdf |
| Ending Page | 5636 |
| Page Count | 8 |
| Starting Page | 5629 |
| DOI | 10.1182/blood-2008-02-139899 |
| Journal | Blood |
| Issue Number | 12 |
| Volume Number | 111 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2008-06-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Human Memory Journal: Blood (Vol- 121, Issue- 12) |
| Content Type | Text |
| Resource Type | Article |
