NDLI: Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl<sub>2</sub>)-induced pulmonary toxicity in broiler chickens

Please wait, while we are loading the content...

An in vivo study in mice: mother's gestational exposure to organophosphorus pesticide retards the division and migration process of neural progenitors in the fetal developing brain

Mussel-inspired PEGylated carbon nanotubes: biocompatibility evaluation and drug delivery applications

Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage

Development of predictive QSAR models for Vibrio fischeri toxicity of ionic liquids and their true external and experimental validation tests

Epigenetic disruption and glucose homeostasis changes following low-dose maternal bisphenol A exposure

Investigations of the genotoxic properties of two synthetic cathinones (3-MMC, 4-MEC) which are used as psychoactive drugs

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl₂)-induced pulmonary toxicity in broiler chickens

Proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both in vitro and in vivo

Lipopolysaccharide attached to urban particulate matter 10 suppresses immune responses in splenocytes while particulate matter itself activates NF-κB

Silica nanoparticles induce start inhibition of meiosis and cell cycle arrest via down-regulating meiotic relevant factors

Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

Fluoride-induced headkidney macrophage cell apoptosis involves activation of the CaMKIIg-ERK 1/2-caspase-8 axis: the role of superoxide in initiating the apoptotic cascade

Back cover

Toxicology Research Vol - 5 Issue - 4

Toxicology Research Vol - 5 Issue - 3

Toxicology Research Vol - 5 Issue - 2

Toxicology Research Vol - 5 Issue - 1

Toxicology Research Vol -4

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl₂)-induced pulmonary toxicity in broiler chickens

Content Provider	Royal Society of Chemistry (RSC)
Author	Fang, Jing Deng, Junliang Guo, Hongrui Cui, Hengmin Zuo, Zhicai Zhao, Ling Deng, Jie Wang, Xun
Copyright Year	2016
Abstract	The respiratory system is the primary target of nickel or nickel compound toxicity after inhalation exposure. There are no reports on the effects of nickel or nickel compounds on the lung via dietary administration at present. This study aimed to investigate pulmonary toxicity induced by dietary NiCl2 in broiler chickens by using histopathology, qRT-PCR, and ELISA. In comparison with the control group, NiCl2 intake induced oxidative damage to DNA (upregulation of 8-OHdG) and lipid peroxidation (upregulation of MDA), which was associated with the upregulation of NO and the downregulation of the expression levels and activities of pulmonary CuZn-SOD, Mn-SOD, CAT, GSH-Px, GR and GST mRNA. Also, the T-AOC activity, GSH content, ability to inhibit the generation of hydroxyl radicals, and ratio of GSH/GSSG were decreased in the groups treated with NiCl2. Concurrently, the mRNA expression levels of iNOS, TNF-α, COX-2, IL-1β, IL-6, IL-8, IL-18 and IFN-γ were increased via the activation of NF-κB, and the mRNA expression levels of anti-inflammatory mediators including IL-2, IL-4 and IL-13 were decreased in the groups treated with NiCl2. The above-mentioned results were the first to demonstrate that NiCl2 intake induced pulmonary oxidative stress and inflammatory responses via the dietary pathway, which subsequently contributed to histopathological lesions and dysfunction.
Starting Page	1421
Ending Page	1433
Page Count	13
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c6tx00197a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Glutathione disulfide Lung Lipid peroxidation MDA Respiratory system Interleukin 6 NF-κB Tumor necrosis factor alpha Interleukin 4 Histopathology Messenger RNA Interleukin 2 Hydroxyl radical Interleukin 8 Real-time polymerase chain reaction Interleukin 13 SOD2 Interleukin 1 beta Interleukin 18 Prostaglandin-endoperoxide synthase 2 DNA Nickel(II) chloride Nickel Broiler ELISA Interferon gamma
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Flavonoids from persimmon (Diospyros kaki) leaves (FPL) attenuate H₂O₂-induced apoptosis in MC3T3-E1 cells via the NF-κB pathway

UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin

Vitamin C exerts beneficial hepatoprotection against Concanavalin A-induced immunological hepatic injury in mice through inhibition of NF-κB signal pathway

Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κB signaling

Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice

Nickel chloride (NiCl2) induces endoplasmic reticulum (ER) stress by activating UPR pathways in the kidney of broiler chickens.

Chemopreventive properties of raisins originating from Greece in colon cancer cells

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-κB signaling in human lung epithelial cells

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl₂)-induced pulmonary toxicity in broiler chickens

Similar Documents

Flavonoids from persimmon (Diospyros kaki) leaves (FPL) attenuate H2O2-induced apoptosis in MC3T3-E1 cells via the NF-κB pathway

UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin

Vitamin C exerts beneficial hepatoprotection against Concanavalin A-induced immunological hepatic injury in mice through inhibition of NF-κB signal pathway

Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κB signaling

Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice

Nickel chloride (NiCl2) induces endoplasmic reticulum (ER) stress by activating UPR pathways in the kidney of broiler chickens.

Chemopreventive properties of raisins originating from Greece in colon cancer cells

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-κB signaling in human lung epithelial cells

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl2)-induced pulmonary toxicity in broiler chickens

Flavonoids from persimmon (Diospyros kaki) leaves (FPL) attenuate H₂O₂-induced apoptosis in MC3T3-E1 cells via the NF-κB pathway

Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl₂)-induced pulmonary toxicity in broiler chickens