NDLI: Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage

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Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Jun Ma, Lu Xing, Xiumei Wang, Xilan Li, Chenggui Xie, Lang Chen, Wen Chen, Li Li, Daochuan Zeng, Qibing Zhang, Aihua
Copyright Year	2016
Abstract	Endemic arsenic poisoning is a worldwide disease and many studies show that arsenic has obvious genetic toxicity. However, the mechanism of arsenic-induced genetic damage is unclear. In this study, coal-fired arsenic poisoning patients in the Guizhou Province, China, were selected as research subjects. Through an analysis of the relationship between genetic damage and histone modification levels and by comparing the control and arsenic poisoning groups, further analysis of their relationship was carried out, the aim being to explore the role of histone modification in arsenic-induced genetic damage. The result shows that arsenic may inhibit the modification level of H4K20me2 and H3K9me2, and increase the modification of H3K36me3, involved in the repair of DNA damage induced by arsenic. This study could provide a new pathway for studies of the genetic toxicity of arsenic.
Starting Page	1380
Ending Page	1387
Page Count	8
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c6tx00117c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Arsenic poisoning Arsenic China DNA Guizhou Province Histone Guizhou
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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