NDLI: Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κB signaling

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Oral administration of geraniol ameliorates acute experimental murine colitis by inhibiting pro-inflammatory cytokines and NF-κB signaling

Content Provider	Royal Society of Chemistry (RSC)
Author	Medicherla, Kanakaraju Sahu, Bidya Dhar Sudhakar, Godi Kumar, Jerald Mahesh Sistla, Ramakrishna Kuncha, Madhusudana
Copyright Year	2015
Abstract	Ulcerative colitis is associated with a considerable reduction in the quality of life of patients. The use of phyto-ingredients is becoming an increasingly attractive approach for the management of colitis. Geraniol is a monoterpene with anti-inflammatory and antioxidative properties. In this study, we investigated the therapeutic potential of geraniol as a complementary and alternative medicine against dextran sulphate sodium (DSS)-induced ulcerative colitis in mice. Disease activity indices (DAI) comprising body weight loss, presence of occult blood and stool consistency were assessed for evaluation of colitis symptoms. Intestinal damage was assessed by evaluating colon length and its histology. Pre-treatment with geraniol significantly reduced the DAI score, improved stool consistency (without occult blood) and increased the colon length. The amount of pro-inflammatory cytokines, specifically TNF-α, IL-1β and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice. Western blot analyses revealed that geraniol interfered with NF-κB signaling by inhibiting NF-κB (p65)-DNA binding, and IκBα phosphorylation, degradation and subsequent increase in nuclear translocation. Moreover, the expressions of downstream target pro-inflammatory enzymes such as iNOS and COX-2 were significantly reduced by geraniol. Pre-treatment with geraniol also restored the DSS-induced decline in antioxidant parameters such as reduced glutathione and superoxide dismutase activity and attenuated the increase in lipid peroxidation marker, thiobarbituric acid reactive substances and nitrative stress marker, nitrites in colon tissue. Thus, our results suggest that geraniol is a potential therapeutic agent for inflammatory bowel disease.
Starting Page	2984
Ending Page	2995
Page Count	12
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	9
Journal	Food & Function
DOI	10.1039/c5fo00405e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DSS Ulcerative colitis Colitis Geraniol Monoterpene Antioxidant Alternative medicine Dextran Sodium Occultation Large intestine Histology Tumor necrosis factor alpha Interleukin 1 beta Interleukin 6 Myeloperoxidase Western blot NF-κB DNA IκBα Phosphorylation Prostaglandin-endoperoxide synthase 2 Glutathione Superoxide dismutase Lipid peroxidation Acid Inflammatory bowel disease
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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