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An in vivo study in mice: mother's gestational exposure to organophosphorus pesticide retards the division and migration process of neural progenitors in the fetal developing brain

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Toxicology Research Vol - 5 Issue - 4

Toxicology Research Vol - 5 Issue - 3

Toxicology Research Vol - 5 Issue - 2

Toxicology Research Vol - 5 Issue - 1

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An in vivo study in mice: mother's gestational exposure to organophosphorus pesticide retards the division and migration process of neural progenitors in the fetal developing brain

Content Provider	Royal Society of Chemistry (RSC)
Author	Wu, Xiu-Zhong Wang, Ting-Ting Chen, Xiao-Ping Wang, Da-Wei Chao, Yong-Sheng
Copyright Year	2016
Abstract	Background: Widely utilized pesticides such as chlorpyrifos (CPF) can cause cognitive abnormalities, neurotransmitter disruptions and brain cytoarchitecture deficits in adulthood due to exposure in the prenatal period, but the mechanism underlying the development and maintenance of such neurotoxicity in embryonic neurogenesis remains largely unclear. Using embryonic neocortex slices, we investigated mitosis population constituents and characteristic interkinetic nuclear migration (INM) to evaluate the CPF effects on the proliferation process of neural progenitors. Methods: Gestational days (GD) 14 and GD 7.5–11.5 ICR dams were exposed to 5 mg kg−1 of CPF to investigate immediate toxicity and sustained toxicity. Proliferating nuclei were labeled with 50 mg kg−1 of Brdu at 1, 3, 6 and 9 hours before samples were collected. The mitoses count and Brdu positive nuclei (BPN) location were measured and analyzed in standard sections of the embryonic dorsolateral cortex. Results: CPF reduced the mitoses count in the primary progenitors but not in the secondary progenitors which are time sustained. CPF retarded BPN migration with a 6–9 μm delay of the relative location in the immediate groups and a 3–6 μm delay in the sustained ones. CPF had no or little effects on the global mitoses count and BPN count. Conclusion: Prenatal CPF exposure disrupts the proliferation process of primary progenitors in the embryonic dorsolateral cortex immediately and with sustained effects, which may contribute to explain the toxicity mechanism in early neurogenesis.
Starting Page	1359
Ending Page	1370
Page Count	12
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c5tx00282f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chlorpyrifos Neurotoxicity Cerebral cortex Mitosis Micrometre CPF Neurotransmitter Cytoarchitecture Neocortex Neurogenesis Brdu
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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An in vivo study in mice: mother's gestational exposure to organophosphorus pesticide retards the division and migration process of neural progenitors in the fetal developing brain