NDLI: Quantum dots exposure alters both development and function of D-type GABAergic motor neurons in nematode Caenorhabditis elegans

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Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Quantum dots exposure alters both development and function of D-type GABAergic motor neurons in nematode Caenorhabditis elegans

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Dayong Wang, Xiong Li, Yiping Wu, Qiuli Zhao, Yunli Tang, Meng
Copyright Year	2015
Abstract	We examined the in vivo quantum dots (QDs) neurotoxicity and the underlying mechanism using Caenorhabditis elegans D-type GABAergic motor neurons as the assay system. Prolonged exposure to low concentrations of CdTe QDs caused damage on both the development and function of D-type motor neurons, and resulted in translocation of CdTe QDs into D-type motor neurons. In addition to oxidative stress, cell identity was also involved in the induction of the toxicity of QDs on D-type motor neurons. ZnS surface coating blocked CdTe QDs translocation and maintained cell identity, thereby suppressing CdTe QDs neurotoxicity. For the underlying mechanism, we hypothesized that both translocation into the targeted neurons and alterations in the development and function of those targeted neurons contribute to the induction of CdTe QDs neurotoxicity. Considering the conserved property of GABAergic neurons during evolution, our data will shed light on our understanding of the potential risks of QDs to the nervous systems of animals.
Starting Page	399
Ending Page	408
Page Count	10
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	2
Journal	Toxicology Research
DOI	10.1039/c4tx00207e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Neurotoxicity Staurogyne elegans Quantum mechanics Gamma-Aminobutyric acid D-type asteroid
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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