NDLI: An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

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An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans

Content Provider	Semantic Scholar
Author	Shen, Yu Wen, Quan Liu, He Zhong, Connie Qin, Yuqi Natasha Harris, Gareth P. Kawano, Taizo Wu, Min Xu, Tianqi Samuel, Aravinthan D. T. Zhang, Yun Xia
Copyright Year	2016
Abstract	As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor neurons generate undulatory activity patterns that correlate with head bending and the activity of RME causally links with head bending amplitude. The undulatory activity of RME is regulated by a pair of cholinergic head motor neurons SMD, which facilitate head bending, and inhibits SMD to limit head bending. The extrasynaptic neurotransmission between SMD and RME provides a gain control system to set head bending amplitude to a value correlated with optimal efficiency of forward movement.
Starting Page	2290
Ending Page	2300
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTQxOTcvZWxpZmUtMTQxOTctZmlndXJlcy12MS5wZGY=/elife-14197-figures-v1.pdf?_hash=B3mB9Z0d%2Bzg5K8sPFeVoCxiWd0B0y%2BBuhZmZ%2Bs/%2B8fk%3D
Alternate Webpage(s)	https://dash.harvard.edu/bitstream/handle/1/27320436/4854516.pdf?sequence=1
Alternate Webpage(s)	http://scholar.harvard.edu/files/aravisamuel/files/elife-14197-v1.pdf
Alternate Webpage(s)	https://scholar.harvard.edu/files/aravisamuel/files/elife-14197-v1.pdf
PubMed reference number	4854516
Alternate Webpage(s)	https://doi.org/10.7554/eLife.14197
DOI	10.7554/elife.14197
Journal	eLife
Volume Number	5
Language	English
Access Restriction	Open
Subject Keyword	Bending - Changing basic body position CNS disorder Caenorhabditis elegans Decompression Sickness Invertebrates Motor Neurons Neurotransmitters Receptor Mediated Endocytosis Synaptic Transmission Thioctic Acid Vertebrates gamma-Aminobutyric Acid
Content Type	Text
Resource Type	Article

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