NDLI: Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats

Please wait, while we are loading the content...

Expression of the Shh/Bmp4 signaling pathway during the development of anorectal malformations in a male rat model of prenatal exposure to di(n-butyl) phthalate

Exposure to low dose cadmium enhances FL83B cells proliferation through down-regulation of caspase-8 by DNA hypermethylation

Dibutyl phthalate induced oxidative stress does not lead to a significant adjuvant effect on a mouse asthma model

Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans

Assessment of in vivo chronic toxicity of chitosan and its derivates used as oral insulin carriers

Cardiac mitochondrial oxidative stress and dysfunction induced by arsenic and its amelioration by diallyl trisulphide

Aroclor 1254 impairs the development of ovarian follicles by inducing the apoptosis of granulosa cells

Quantifying the pharmaceutical industry's contribution to published 3Rs research 2002–2012

Modulation of the chelatable Zn pool in the brain by diethyldithiocarbamate is associated with behavioral impairment in adult zebrafish

Persistent organochlorine pesticides and oxidant/antioxidant status in the placental tissue of the women with full-term and pre-term deliveries

Insulin signaling regulates the toxicity of traffic-related PM_2.5 on intestinal development and function in nematode Caenorhabditis elegans

Involvement of neurotrophins and related signaling genes in TiO₂ nanoparticle – induced inflammation in the hippocampus of mice

Mitochondrial dysfunction and oxidative damage in the liver and kidney of rats following exposure to copper nanoparticles for five consecutive days

A gene signature for gold nanoparticle-exposed human cell lines

Impact of manganese on the hippocampus metabolism in the context of MEMRI: a proton HRMAS MRS study

Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway

Quantum dots exposure alters both development and function of D-type GABAergic motor neurons in nematode Caenorhabditis elegans

Cytotoxic effects and cellular oxidative mechanisms of metallic nanoparticles on renal tubular cells: impact of particle solubility

Transcriptomic alterations induced by Monuron in rat and human renal proximal tubule cells in vitro and comparison to rat renal-cortex in vivo

Regulation of bacterial lipopolysaccharide in liver toxicity caused by chlorpromazine and Z24 in Sprague-Dawley rats

Biochemical and behavioral deficits in the lobster cockroach Nauphoeta cinerea model of methylmercury exposure

In silico prediction of chemical aquatic toxicity with chemical category approaches and substructural alerts

Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-β signalling

A modified weight-of-evidence approach to evaluate the allergenic potential of food proteins

Toxic effect comparison of three typical sterilization nanoparticles on oxidative stress and immune inflammation response in rats

Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures

Endosulfan induced the arrest of the cell cycle through inhibiting the signal pathway mediated by PKC-α and damaging the cytoskeleton in spermatogonial cells of mice in vitro

Identifying potential protein targets for toluene using a molecular similarity search, in silico docking and in vitro validation

Correction: Melamine in breast milk

Back cover

Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Reddy, P. Sreenivasula Reddy, K. Pratap Girish, B. P.
Copyright Year	2015
Abstract	In this study, we evaluated reproductive toxic effects of benzo(a)pyrene (BaP) in adult male Wistar rats. Rats received intra-peritoneal injections containing BaP at a dose of 1, 10 or 100 μg per kg bw on alternate days for 60 days and were analyzed for fertility. Control and experimental male rats were cohabited with control female rats and sperm positive female rats were analyzed for paternal-mediated reproductive and developmental toxicity. Dose dependent reduction in the litter size and crown rump length was apparent in pups sired by experimental males. The developmental landmarks were comparable among pups in all groups except for the delay in testis descent and vaginal opening which was observed in experimental pups. After completion of fertility studies, rats were sacrificed and analyzed for reproductive endpoints. The relative weights of the testes, caput epididymis, cauda epididymis, seminal vesicles and prostate gland were decreased significantly in BaP exposed animals. Daily sperm production and epididymal sperm count, motility and viability decreased significantly in a dose dependent manner in BaP treated rats. Also, there was a dose dependent decrease in the testicular steroidogenic enzyme activities. Additionally, serum testosterone levels were decreased in BaP treated animals. In silico studies revealed the binding affinity of BaP to simulated StAR protein in the hydrophobic tunnel region. It can be concluded that chronic exposure to sub-lethal doses of BaP affects steroidogenesis and spermatogenesis resulting in reduced fertility in adult male rats.
Starting Page	223
Ending Page	232
Page Count	10
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	2
Journal	Toxicology Research
DOI	10.1039/c4tx00121d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Steroid Seminal vesicle Spermatogenesis Steroidogenic enzyme Cauda Hydrophobe Testicle Caput Protein Pyrene Testosterone Epididymis In silico Prostate
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

Testicular and epididymal toxicity induced by benzo(a)pyrene, alcohol, and their combination in Wistar rats

Subchronic cyanide toxicity on male reproductive system of albino rat

Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro-in silico approach.

Benzo[a]pyrene reduces testosterone production in rat Leydig cells via a direct disturbance of testicular steroidogenic machinery.

Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats.

Endocrine and testicular changes induced by olanzapine in adult Wistar rats.

Increased Sensitivity to Testicular Toxicity of Transplacental Benzo[a]pyrene Exposure in Male Glutamate Cysteine Ligase Modifier Subunit Knockout (Gclm−/−) Mice

Benzo[a]pyrene Effects on Reproductive Endpoints in Fundulus heteroclitus

Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats

Similar Documents

Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

Testicular and epididymal toxicity induced by benzo(a)pyrene, alcohol, and their combination in Wistar rats

Subchronic cyanide toxicity on male reproductive system of albino rat

Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro-in silico approach.

Benzo[a]pyrene reduces testosterone production in rat Leydig cells via a direct disturbance of testicular steroidogenic machinery.

Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats.

Endocrine and testicular changes induced by olanzapine in adult Wistar rats.

Increased Sensitivity to Testicular Toxicity of Transplacental Benzo[a]pyrene Exposure in Male Glutamate Cysteine Ligase Modifier Subunit Knockout (Gclm−/−) Mice

Benzo[a]pyrene Effects on Reproductive Endpoints in Fundulus heteroclitus

Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats