NDLI: Palladium modified porous silicon as multi-functional MALDI chip for serum peptide detection

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High-throughput screening of triplex DNA binders from complicated samples by 96-well pate format in conjunction with peak area-fading UHPLC-Orbitrap MS

Correction: Photoinduced electron transfer as a design concept for luminescent redox indicators

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The Analyst Vol - 142 Issue - 3

The Analyst Vol - 142 Issue - 2

Palladium modified porous silicon as multi-functional MALDI chip for serum peptide detection

Content Provider	Royal Society of Chemistry (RSC)
Author	Wu, Jianmin Liang, Xiao Li, Xiao Tan, Jie Chen, Xiaoming
Copyright Year	2017
Abstract	Interest in using mesoporous materials for peptidomic research has increased recently. The present study reports a new type of matrix assisted laser desorption/ionization (MALDI) plate derived from electrochemically etched porous silicon (PSi) whose surface was modified with palladium nanoparticles (PdNPs). Owing to the well-tailored pore size and the molecular filtration effect of the PSi, peptides in serum samples can be selectively captured and enriched in the pore channel, thereby eliminating the interference from large proteins in subsequent MALDI-MS detection. On the other hand, the PdNPs with localized surface plasmon resonance (LSPR) effect can help to enhance the efficiency of energy absorption in the UV region. Meanwhile, the charge separation effect between the PSi semiconductor and PdNPs also can be applied to promote the accumulation of positive charges on PdNPs, resulting in an improvement in laser desorption/ionization (LDI) efficiency under positive linear detection mode. The interplay among these unique properties of PSi and PdNPs can synergistically increase the overall sensitivity in serum peptide detection. Using this technology, serum sample can be directly detected on the PSi-PdNPs chip without complicated pretreatment process. Therefore, a high fidelity serum peptide fingerprint can be acquired in a high throughput way. With the assistance of statistical analysis, colorectal cancer patients and healthy people can be accurately distinguished based on the serum peptide fingerprints.
Starting Page	586
Ending Page	590
Page Count	5
File Format	HTM / HTML PDF
ISSN	00032654
Volume Number	142
Issue Number	4
Journal	The Analyst
DOI	10.1039/c6an02165d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	LDI Mesoporous material Semiconductor Fingerprint Ionization Laser Colorectal cancer Interplay Entertainment Extracellular matrix Surface plasmon resonance Surface plasmon Peptide
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry Electrochemistry

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