NDLI: Enhancement effect of essential oils from the fruits and leaves of Alpinia oxyphylla on skin permeation and deposition of indomethacin

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Wanping Kong, Weijun Luo, Jiaoyang Yang, Meihua Zhao, Xiangsheng Dou, Xiaowen Wang, Yuting Feng, Huanhuan Li, Qiong
Copyright Year	2015
Abstract	Essential oils from plants are gaining increasing attention as potential chemical penetration enhancers. This study aimed to investigate the enhancement effect of essential oils from the fruits and leaves of Alpinia oxyphylla on skin permeation and deposition of indomethacin. In vitro permeation experiments were performed in Franz-type cells through rat skin, and the amount of drug passing through into the receptor phase was analyzed by ultra performance liquid chromatography-photodiode array (UPLC-PDA). Ultra fast liquid chromatography coupled with tandem mass spectrometry (UFLC-MS/MS) was used to analyze the plasma drug concentration of indomethacin to examine the enhancement effect of essential oils in an in vivo rat model of drug delivery. Both oils demonstrated a significant enhancement effect on drug delivery and skin deposition (p < 0.05). Particularly, at 3% concentration, enhancement ratios of fruit oil and leaf oil were 10.16 and 4.61, respectively, which were both significantly higher than that of the commonly used enhancer, Azone (2.04). Major constituents of both oils were identified by gas chromatography-mass spectrometry (GC-MS). It may be deduced that higher content hydrocarbon terpenes in the fruit oil contribute to the increased enhancement effect relative to leaf oil. The skin irritation test indicated that both oils at certain concentrations (1%, 3%, and 5%) did not cause obvious erythema or edema in rabbits. Considering their enhanced drug permeation and low skin irritation, essential oils from Alpinia oxyphylla could be novel penetration enhancers and have promising applications in transdermal drug delivery and cosmetics.
Starting Page	38910
Ending Page	38917
Page Count	8
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	5
Issue Number	49
Journal	RSC Advances
DOI	10.1039/c5ra05422b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Estrogen receptor Gas chromatography\u2013mass spectrometry Edema Hydrocarbon Indometacin Drug delivery High-performance liquid chromatography Erythema Mass spectrometry Transdermal patch Alpinia Blood plasma
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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