NDLI: Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Yeping Huang, Liying Xu, Jingbo Xu, Yun Cheng, Xiaonong Wang, Junli
Copyright Year	2015
Abstract	The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier. Novel chitosan–ZnSe/ZnS (CS–ZnSe/ZnS) nanoparticles were synthesized by a one-step ionic gelation technique, with ZnSe/ZnS quantum dots (ZnSe/ZnS QDs) as cross-linking agent and for fluorescent labeling. The approach not only avoids the use of emulsifiers and chemical cross-linking agents but also prevents the possibility of damage to drugs. The fluorescent CS–ZnSe/ZnS nanoparticles were about 100–500 nm in size and stable in a physiological environment. Low cytotoxicity was ensured by investigation with mouse lung carcinoma cells. The cell viability remained 99% when the concentration of CS–ZnSe/ZnS nanoparticles increased to 200 μg mL−1. In the in vitro drug release experiment, 5-fluorouracil (5-Fu) loaded within CS–ZnSe/ZnS nanoparticles had more preferable sustained-release performance and longer equilibrium time compared with that of the pure 5-Fu. The fluorescent CS–ZnSe/ZnS nanoparticles are expected to be used for biological fluorescent labeling and drug carriers.
Starting Page	38810
Ending Page	38817
Page Count	8
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	5
Issue Number	49
Journal	RSC Advances
DOI	10.1039/c5ra02933c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Quantum Lung cancer The Cell Cytotoxicity Chitosan Cross-link Laboratory mouse Fluorouracil
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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