NDLI: Nanostructured nanoparticles of self-assembled lipid pro-drugs as a route to improved chemotherapeutic agents

Content Provider	Royal Society of Chemistry (RSC)
Author	Krodkiewska, Irena Kimpton, Kathleen Moghaddam, Minoo J. Waddington, Lynne J. Sagnella, Sharon M. Drummond, Calum J. Gong, Xiaojuan Conn, Charlotte E.
Copyright Year	2011
Abstract	We demonstrate that oral delivery of self-assembled nanostructured nanoparticles consisting of 5-fluorouracil (5-FU) lipid prodrugs results in a highly effective, target-activated, chemotherapeutic agent, and offers significantly enhanced efficacy over a commercially available alternative that does not self-assemble. The lipid prodrug nanoparticles have been found to significantly slow the growth of a highly aggressive mouse 4T1 breast tumour, and essentially halt the growth of a human MDA-MB-231 breast tumour in mouse xenografts. Systemic toxicity is avoided as prodrug activation requires a three-step, enzymatic conversion to 5-FU, with the third step occurring preferentially at the tumour site. Additionally, differences in the lipid prodrug chemical structure and internal nanostructure of the nanoparticle dictate the enzymatic conversion rate and can be used to control sustained release profiles. Thus, we have developed novel oral nanomedicines that combine sustained release properties with target-selective activation.
Starting Page	919
Ending Page	924
Page Count	6
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	3
Issue Number	3
Journal	Nanoscale
DOI	10.1039/c0nr00781a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Mouse Nanoparticle List of breast cancer cell lines Nanostructure Prodrug Lipid Fluorouracil
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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