NDLI: Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Mahmoudi, Morteza Shokrgozar, Mohammad A. Vali, Hojatollah Stroeve, Pieter Laurent, Sophie Sardari, Soroush Moghadam, Mojgan K.
Copyright Year	2011
Abstract	The understanding of the interactions between nanomaterials and proteins is of extreme importance in medicine. In a biological fluid, proteins can adsorb and associate with nanoparticles, which can have significant impact on the biological behavior of the proteins and the nanoparticles. We report here on the interactions of iron saturated human transferrin protein with both bare and polyvinyl alcohol coated superparamagnetic iron oxide nanoparticles (SPIONs). The exposure of human transferrin to SPIONs results in the release of iron, which changes the main function of the protein, which is the transport of iron among cells. After removal of the magnetic nanoparticles, the original protein conformation is not recovered, indicating irreversible changes in transferrin conformation: from a compact to an open structure.
Starting Page	1127
Ending Page	1138
Page Count	12
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	3
Issue Number	3
Journal	Nanoscale
DOI	10.1039/c0nr00733a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Transferrin Nanomaterials Polyvinyl alcohol Iron oxide nanoparticle Protein
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles