NDLI: A systems biology approach to reconcile metabolic network models with application to Synechocystis sp. PCC 6803 for biofuel production

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A systems biology approach to reconcile metabolic network models with application to Synechocystis sp. PCC 6803 for biofuel production

Content Provider	Royal Society of Chemistry (RSC)
Author	Mohammadi, Reza Bidkhori, Gholamreza Zahiri, Javad Niroomand, Mohammad Javad Masoudi-Nejad, Ali Fallah-Mehrabadi, Jalil
Copyright Year	2016
Abstract	Production of biofuels has been one of the promising efforts in biotechnology in the past few decades. The perspective of these efforts can be reduction of increasing demands for fossil fuels and consequently reducing environmental pollution. Nonetheless, most previous approaches did not succeed in obviating many big challenges in this way. In recent years systems biology with the help of microorganisms has been trying to overcome these challenges. Unicellular cyanobacteria are widespread phototrophic microorganisms that have capabilities such as consuming solar energy and atmospheric carbon dioxide for growth and thus can be a suitable chassis for the production of valuable organic materials such as biofuels. For the ultimate use of metabolic potential of cyanobacteria, it is necessary to understand the reactions that are taking place inside the metabolic network of these microorganisms. In this study, we developed a Java tool to reconstruct an integrated metabolic network of a cyanobacterium (Synechocystis sp. PCC 6803). We merged three existing reconstructed metabolic networks of this microorganism. Then, after modeling for biofuel production, the results from flux balance analysis (FBA) disclosed an increased yield in biofuel production for ethanol, isobutanol, 3-methyl-1-butanol, 2-methyl-1-butanol, and propanol. The numbers of blocked reactions were also decreased for 2-methyl-1-butanol production. In addition, coverage of the metabolic network in terms of the number of metabolites and reactions was increased in the new obtained model.
Starting Page	2552
Ending Page	2561
Page Count	10
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	12
Issue Number	8
Journal	Molecular BioSystems
DOI	10.1039/c6mb00119j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Java Metabolic network FBA Ethanol Carbon dioxide Synechocystis Biofuel Isobutanol Isoamyl alcohol Flux balance analysis 2-Methyl-1-butanol Systems biology British Academy Cyanobacteria Solar energy Fossil fuel Genetic engineering Microorganism
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Light-induced production of isobutanol and 3-methyl-1-butanol by metabolically engineered cyanobacteria

A Computational Analysis of Stoichiometric Constraints and Trade-Offs in Cyanobacterial Biofuel Production

Sustainable production of photosynthetic isobutanol and 3-methyl-1-butanol in the cyanobacterium Synechocystis sp. PCC 6803

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Glycogen and Extracellular Glucose Estimation from Cyanobacteria Synechocystis sp. PCC 6803.

The genome sequence of Synechocystis sp. PCC 6803 substrain GT-T and its implications for the evolution of PCC 6803 substrains.

Alcohol dehydrogenase AdhA plays a role in ethanol tolerance in model cyanobacterium Synechocystis sp. PCC 6803

Increased biomass production and glycogen accumulation in apcE gene deleted Synechocystis sp. PCC 6803

A systems biology approach to reconcile metabolic network models with application to Synechocystis sp. PCC 6803 for biofuel production

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