NDLI: Molecular and genetic inflammation networks in major human diseases

Please wait, while we are loading the content...

Identification of novel selective MMP-9 inhibitors as potential anti-metastatic lead using structure-based hierarchical virtual screening and molecular dynamics simulation

Selective targeting of MAPK family kinases JNK over p38 by rationally designed peptides as potential therapeutics for neurological disorders and epilepsy

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

A systems biology approach to reconcile metabolic network models with application to Synechocystis sp. PCC 6803 for biofuel production

NMR analysis of the human saliva metabolome distinguishes dementia patients from matched controls

MSLVP: prediction of multiple subcellular localization of viral proteins using a support vector machine

iNuc-STNC: a sequence-based predictor for identification of nucleosome positioning in genomes by extending the concept of SAAC and Chou's PseAAC

A systems biology and proteomics-based approach identifies SRC and VEGFA as biomarkers in risk factor mediated coronary heart disease

The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma

Unraveling the conformational determinants of LARP7 and 7SK small nuclear RNA by theoretical approaches

Molecular dynamics simulations provide insights into the substrate specificity of FAOX family members

Substrate transport pathway inside outward open conformation of EmrD: a molecular dynamics simulation study

Analysis of the optimality of the standard genetic code

Back cover

Molecular BioSystems Vol - 12 Issue - 7

Molecular BioSystems Vol - 12 Issue - 6

Molecular BioSystems Vol -9

Molecular BioSystems Vol -8

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Molecular and genetic inflammation networks in major human diseases

Content Provider	Royal Society of Chemistry (RSC)
Author	Yang, Xia Forst, Christian V. Zhao, Yongzhong Wang, I-Ming Zhang, Bin Sayegh, Camil E.
Copyright Year	2016
Abstract	It has been well-recognized that inflammation alongside tissue repair and damage maintaining tissue homeostasis determines the initiation and progression of complex diseases. Albeit with the accomplishment of having captured the most critical inflammation-involved molecules, genetic susceptibilities, epigenetic factors, and environmental factors, our schemata on the role of inflammation in complex diseases remain largely patchy, in part due to the success of reductionism in terms of research methodology per se. Omics data alongside the advances in data integration technologies have enabled reconstruction of molecular and genetic inflammation networks which shed light on the underlying pathophysiology of complex diseases or clinical conditions. Given the proven beneficial role of anti-inflammation in coronary heart disease as well as other complex diseases and immunotherapy as a revolutionary transition in oncology, it becomes timely to review our current understanding of the molecular and genetic inflammation networks underlying major human diseases. In this review, we first briefly discuss the complexity of infectious diseases and then highlight recently uncovered molecular and genetic inflammation networks in other major human diseases including obesity, type II diabetes, coronary heart disease, late onset Alzheimer’s disease, Parkinson’s disease, and sporadic cancer. The commonality and specificity of these molecular networks are addressed in the context of genetics based on genome-wide association study (GWAS). The double-sword role of inflammation, such as how the aberrant type 1 and/or type 2 immunity leads to chronic and severe clinical conditions, remains open in terms of the inflammasome and the core inflammatome network features. Increasingly available large Omics and clinical data in tandem with systems biology approaches have offered an exciting yet challenging opportunity toward reconstruction of more comprehensive and dynamic molecular and genetic inflammation networks, which hold great promise in transiting network snapshots to video-style multi-scale interplays of disease mechanisms, in turn leading to effective clinical intervention.
Starting Page	2318
Ending Page	2341
Page Count	24
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	12
Issue Number	8
Journal	Molecular BioSystems
DOI	10.1039/c6mb00240d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Obesity Homeostasis Oncology Inflammation Inflammasome Reductionism Coronary artery disease Diabetes mellitus type 2 Genome-wide association study Systems biology Data integration Immunotherapy Omics Epigenetics Revolution Cancer Immune system
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies

Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks

Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes

Association of Obesity Indices with Type 2 Diabetes Mellitus and Coronary Artery Disease

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease

Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.

Genetic Determinants of Type 2 Diabetes in Asians.

MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population.

Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.

Molecular and genetic inflammation networks in major human diseases

Similar Documents

Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies

Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks

Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes

Association of Obesity Indices with Type 2 Diabetes Mellitus and Coronary Artery Disease

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease

Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.

Genetic Determinants of Type 2 Diabetes in Asians.

MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population.

Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.

Molecular and genetic inflammation networks in major human diseases