NDLI: iNuc-STNC: a sequence-based predictor for identification of nucleosome positioning in genomes by extending the concept of SAAC and Chou's PseAAC

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Molecular BioSystems Vol - 12 Issue - 7

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iNuc-STNC: a sequence-based predictor for identification of nucleosome positioning in genomes by extending the concept of SAAC and Chou's PseAAC

Content Provider	Royal Society of Chemistry (RSC)
Author	Tahir, Muhammad Hayat, Maqsood
Copyright Year	2016
Abstract	The nucleosome is the fundamental unit of eukaryotic chromatin, which participates in regulating different cellular processes. Owing to the huge exploration of new DNA primary sequences, it is indispensable to develop an automated model. However, identification of novel protein sequences using conventional methods is difficult or sometimes impossible because of vague motifs and the intricate structure of DNA. In this regard, an effective and high throughput automated model “iNuc-STNC” has been proposed in order to identify accurately and reliably nucleosome positioning in genomes. In this proposed model, DNA sequences are expressed into three distinct feature extraction strategies containing dinucleotide composition, trinucleotide composition and split trinucleotide composition (STNC). Various statistical models were utilized as learner hypotheses. Jackknife test was employed to evaluate the success rates of the proposed model. The experiential results expressed that SVM, in combination with STNC, has obtained an outstanding performance on all benchmark datasets. The predicted outcomes of the proposed model “iNuc-STNC” is higher than current state of the art methods in the literature so far. It is ascertained that the “iNuc-STNC” model will provide a rudimentary framework for the pharmaceutical industry in the development of drug design.
Starting Page	2587
Ending Page	2593
Page Count	7
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	12
Issue Number	8
Journal	Molecular BioSystems
DOI	10.1039/c6mb00221h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	STNC Chromatin Nucleosome DNA Eukaryote Feature extraction Drug design Protein Microsoft mobile services
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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iNuc-STNC: a sequence-based predictor for identification of nucleosome positioning in genomes by extending the concept of SAAC and Chou's PseAAC