NDLI: Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.

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Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.

Content Provider	Europe PMC
Author	Perumalsamy, Sangeetha Huri, Hasniza Zaman Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B.
Editor	Banach, Maciej Qadura, Mohammad
Copyright Year	2023
Abstract	Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.
Volume Number	13
PubMed Central reference number	PMC10054456
Issue Number	3
PubMed reference number	36984867
Journal	Metabolites
e-ISSN	22181989
DOI	10.3390/metabo13030427
Language	English
Publisher	MDPI
Publisher Date	2023-03-14
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	insulin resistance type 2 diabetes mellitus atherosclerosis endothelial dysfunction coronary artery disease genetic markers single nucleotide polymorphisms
Content Type	Text
Resource Type	Article
Subject	Biochemistry Endocrinology, Diabetes and Metabolism Molecular Biology

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