NDLI: Visualization of <i>in situ</i> hydrogels by MRI <i>in vivo</i>

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Journal of Materials Chemistry B Vol - 4 Issue - 6

Journal of Materials Chemistry B Vol - 4 Issue - 5

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Visualization of in situ hydrogels by MRI in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Ke Zhuo, Renxi Wang, Lei Luan, Jie Wen, Zhi Liu, Jia Wu, Guangyao Liu, Zhilan
Copyright Year	2016
Abstract	It is of great interest to monitor implants in real-time using non-invasive detecting techniques in interventional therapies or tissue regeneration. In this study, MRI-visible hydrogels that are pH sensitive, injectable and self-healing were prepared based on chitosan and PEG. The macromolecular chelator of Gd(III), Ch–DTPA, was synthesized by functionalization of chitosan with diethylene triamine pentaacetic acid (DTPA). The PEG end-capped with aryl aldehyde, PEG-DA, was prepared as a crosslinker. Based on the Schiff's base reaction, the hydrogels can be obtained quickly just by mixing the aqueous solutions of Ch–DTPA and PEG-DA at ambient temperature. The gelating procedure is pH sensitive, and the hydrogels exhibit self-healing in an environment with a pH value of 4.5–5.3. The morphology of the lyophilized gel was observed by SEM. In vitro release behavior of the hydrogel was tested also using rhodamine B as a model drug. The MRI contrast enhancement effect of Gd(III)-binding hydrogels was investigated both in vitro and in vivo on rats. The results revealed that the hydrogels showed strong signals on T1-weighted MR images, and the hydrogels could always be detected before complete biodegradation. Combining the histology observation, the developed in situ hydrogels are of potential in the application of long-term reporting of implants by MRI.
Starting Page	1343
Ending Page	1353
Page Count	11
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02459e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Schiff PH Chitosan Chelation Diethylenetriamine Acid Pentetic acid Aromaticity Aldehyde Gel Rhodamine Magnetic resonance imaging Biodegradation Histology
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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