NDLI: Dual ligand co-functionalized fluorescent gold nanoclusters for the “turn on” sensing of glutathione in tumor cells

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Journal of Materials Chemistry B Vol - 4 Issue - 6

Journal of Materials Chemistry B Vol - 4 Issue - 5

Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Dual ligand co-functionalized fluorescent gold nanoclusters for the “turn on” sensing of glutathione in tumor cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Gao, Teng Mao, Yaning Luo, Xiliang Liu, Pingping Yu, Xijuan Xu, Shenghao Feng, Xiuying
Copyright Year	2016
Abstract	In this work, we develop a facile one-step strategy for rapidly preparing dual ligand co-functionalized fluorescent gold nanoclusters (Au NCs) and establish a “turn on” approach for the rapid and selective sensing of glutathione (GSH) in aqueous solution and living cells. The as-prepared Au NCs exhibited orange red fluorescence (λem = 608 nm), a long lifetime (5.62 μs), a large stokes shift (>300 nm), and considerable stability and were systematically characterized by using fluorescence spectroscopy, high-resolution transmission electron microscopy (HRTEM), dynamic light scattering (DLS), X-ray photoelectron spectroscopy (XPS), fluorescence lifetime, infrared (IR) spectroscopy and ultraviolet absorption spectroscopy. Based on the fluorescence recovery induced by competitive coordination with Cu2+ between Au NCs and GSH, the present “turn on” approach offers a high sensitivity and excellent selectivity toward GSH detection with a detection limit of 9.7 nM. More importantly, this “turn on” approach could also be successfully applied for visualizing and monitoring the changes in the intracellular GSH level in Hep G2 cells, providing available potential for diagnostic applications.
Starting Page	1270
Ending Page	1275
Page Count	6
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02195b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ligand Glutathione Fluorescence Stokes shift Spectroscopy High-resolution transmission electron microscopy Dynamic light scattering X-ray photoelectron spectroscopy Photoemission spectroscopy Infrared spectroscopy Ultraviolet Hep G2
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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