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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Tian, Gao-Fei Zhang, Yu-Kui Li, Wen-You Liu, Yang He, Xi-Wen |
| Copyright Year | 2016 |
| Abstract | The development of ideal contrast agents was of great importance for multimodal imaging. However, the simple combination of different contrast components always needed long-time preparation and a tough reaction environment. In this study, we introduced a one-step microwave-assisted approach to synthesize lysozyme-capped gold nanoclusters (Lys–Au NCs) rapidly instead of traditional conditions. Irradiation with continuous microwave power shortened the reaction time from several hours to one hour and generated a large red shift (50 nm) of the fluorescence emission. The ultrasmall Lys–Au NCs showed excellent properties, including high quantum yield (19.61%), good stability, low cytotoxicity and good biocompatibility. This eco-friendly nanoprobe provided significant contrast signals in both NIRF (near-infrared fluorescence) and CT (X-ray computed tomography) in vivo imaging. Further conjugation with folic acid made the nanoprobe favorable for targeted fluorescence imaging of cancer cells and tumor-bearing mice. |
| Starting Page | 1276 |
| Ending Page | 1283 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 2050750X |
| Volume Number | 4 |
| Issue Number | 7 |
| Journal | Journal of Materials Chemistry B |
| DOI | 10.1039/c5tb02322j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Irradiation Microwave Fluorescence Quantum Cytotoxicity Biocompatibility CT scan Carboxylic acid Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Materials Science Biomedical Engineering |
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