NDLI: Facile synthesis and <i>in vivo</i> evaluation of biodegradable dendritic MRI contrast agents

Content Provider	Royal Society of Chemistry (RSC)
Author	Qian, Yue Hu, Hongjie Ye, Mingzhou Sui, Meihua Shen, Youqing Tang, Jianbin
Copyright Year	2012
Abstract	Dendritic gadolinium chelates as magnetic resonance imaging (MRI) contrast agents (CAs) have shown great potential in blood pool and tumor imaging due to their enhanced relaxivities (R1s), prolonged blood circulation time, and homogeneous pharmaceutical properties. However, the non-biodegradability of the currently used dendrimers causes long-term retention of toxic gadolinium ions, limiting their clinical applications. Herein, we report a facile synthesis of biodegradable polyester dendrimer-based CAs. The prepared dendritic CAs have nano-sized structures with the hydrodynamic diameters ranging from 2.8 to 8.6 nm, and show high R1s up to 11.7 mM−1 s−1, approximately 2.7 times that of a clinically used small molecule CA (Magnevist). They are slowly hydrolyzed at an acidic pH, but rapidly hydrolyzed at pH 7.4, especially in the presence of esterase. The in vivo evaluation indicates they not only provide much better MRI contrast enhancement than Magnevist, but also show minimal tissue retention of Gd, which is much lower than those of non-biodegradable CAs.
Starting Page	14369
Ending Page	14377
Page Count	9
File Format	HTM / HTML PDF
ISSN	09599428
Volume Number	22
Issue Number	29
Journal	Journal of Materials Chemistry
DOI	10.1039/c2jm32211k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Magnevist Gadolinium Magnetic resonance imaging Biodegradation Polyester Gadopentetic acid PH Esterase
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry

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