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Journal of Materials Chemistry B Vol - 4 Issue - 6

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Journal of Materials Chemistry B Vol -3

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Fluorinated dendrimer for TRAIL gene therapy in cancer treatment

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Hui Cheng, Yiyun Wang, Mingming Zhang, Qiang Liu, Hongmei Wang, Yitong
Copyright Year	2016
Abstract	The delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene into cancer cells is a promising strategy for cancer treatment. However, the low transfection efficacy and/or the toxicity of vectors severely hamper the translation of TRAIL gene therapy into the clinics. In this article, we employed our recently developed fluorinated dendrimer as a vector to deliver plasmid encoding TRAIL (pTRAIL) into cancer cells for cancer treatment, which holds the advantages of both excellent transfection efficacy and low toxicity. Fluorinated poly(amidoamine) dendrimer (G4-F735) represented much higher TRAIL gene transfection efficacy than a series of transfection reagents including poly(ethylene imine) (PEI), SuperFect and Lipofectamine 2000, leading to a much higher cell apoptosis efficacy. The G4-F735/pTRAIL complex, compared with PEI/pTRAIL, could more efficiently destroy three-dimensional multicellular spheroids consisting of MDA-MB-231 cells, and suppress the tumor growth in vivo. Furthermore, G4-F735 showed minimal toxicity in vitro and undetectable systemic toxicity in vivo. From this study, the fluorinated dendrimer offers a promising prospect for TRAIL gene therapy.
Starting Page	1354
Ending Page	1360
Page Count	7
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	4
Issue Number	7
Journal	Journal of Materials Chemistry B
DOI	10.1039/c5tb02712h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Necrosis Ligand TRAIL Gene Cancer Transfection Gene therapy Dendrimer Euclidean vector Plasmid Poly(amidoamine) Power Mac G4 Ethylene Imine Apoptosis List of breast cancer cell lines Treatment as prevention
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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