NDLI: Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE2 and COX-2 expression via nuclear factor-κB

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Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE₂ and COX-2 expression via nuclear factor-κB

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Food & Function Vol - 6 Issue - 4

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Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE₂ and COX-2 expression via nuclear factor-κB

Content Provider	Royal Society of Chemistry (RSC)
Author	Ahmed, Danish Mujeeb, Mohd. Kumar, Vikas Verma, Amita Al-Abbasi, F. A. Anwar, Firoz
Copyright Year	2015
Abstract	The current investigation was undertaken to determine the anti-inflammatory and antioxidant effects of Paederia foetida Linn. (PF) along with its mechanism of action when implemented in tissue protection. HPTLC was used in the identification of the compound quercetin, while in vitro analysis confirmed the significance of the antioxidant and anti-inflammatory action of PF. We initially demonstrated the in vivo anti-inflammatory effect of PF, evaluating it against a variety of phlogistic agents as well as turpentine oil, prostaglandin and arachidonic acid. Groups of rats, fasted overnight, were treated as follows: Group I: normal control (vehicle), Group II: PF (100 mg kg−1), Group III: arthritic control (CFA only, 0.05 ml), Group IV, V, VI: CFA (0.05 ml) + PF (25, 50 and 100 mg kg−1) and Group VII: CFA (0.05 ml) + indomethacin (10 mg per kg b.w.). PF significantly protected against paw edema, arthritic index and body weight alteration induced by Complete Fruend's Adjuvant (CFA). Other observations, like histological and macroscopic changes, were observed in CFA induced inflammation in knee joints. Subcutaneous administration of CFA was accompanied by proinflammatory cytokine status, as appraised by the amplification of interleukin-2 (IL-2), interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α); oxidative stress status was estimated by the enhancement of the level of lipid peroxidation (LPO) and the depletion of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH). Pre-treatment with PF significantly (P < 0.001) protected against CFA induced oxidative stress and proinflammatory cytokines. More prominently, CFA administration augmented tissue and plasma superoxide (O2) and hydrogen peroxide (H2O2) levels, while the PF pre-treatment significantly (P < 0.001) reversed all CFA induced intracellular interruption. Following CFA induced arthritis, PF was tested for its free radical scavenging activity against the DPPH and ABTS radicals and its inhibitory proficiency against COX-1 and COX-2 in vitro. Considering the above, the current research confirmed momentous protection against CFA induced arthritis, which could be attributed to its anti-inflammatory and pro-oxidant nature.
Starting Page	1652
Ending Page	1666
Page Count	15
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	5
Journal	Food & Function
DOI	10.1039/c5fo00178a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DPPH ABTS Linn Paederia Antioxidant Linn Records High-performance thin-layer chromatography Quercetin Turpentine Prostaglandin Acid Indometacin Edema Inflammation Proinflammatory cytokine Interleukin 2 Interleukin-1 family Tumor necrosis factor alpha Oxidative stress Lipid peroxidation Superoxide dismutase Glutathione peroxidase Glutathione Blood plasma Superoxide Oxygen Hydrogen peroxide Free-radical halogenation PTGS1 Pro-oxidant
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE₂ and COX-2 expression via nuclear factor-κB

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Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE2 and COX-2 expression via nuclear factor-κB

Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE₂ and COX-2 expression via nuclear factor-κB