NDLI: Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Kwak, Ho-kyung Lee, Heejae Yi, Hae Chang Cho, Hyunnho Jung, Hana Hwang, Keum Taek
Copyright Year	2015
Abstract	Black raspberry (BRB) seeds are a major waste product after fruit processing. The seeds are abundant in ellagitannins (ET), a class of hydrolysable tannins, which are hydrolyzed to ellagic acid (EA) and further metabolized to urolithin A (UA) and urolithin B (UB), known to be bioavailable in the colon and the prostate. In this study, the anti-cancer activities of these compounds were evaluated on HT-29 colon cancer cells. ET, EA, UA and UB inhibited the proliferation of the cancer cells. EA caused a slight, but significant cell cycle arrest at the G1 phase, and urolithins caused cell cycle arrest at the G2/M phase and upregulated p21 expression. Apoptotic cells were detected by Annexin V-FITC/PI assay when treated with the compounds. Disruption in mitochondrial membrane potential and activation of caspases 8 and 9 suggest that both extrinsic and intrinsic apoptotic pathways may be involved. Activation of caspase 3 and cleavage of PARP further confirmed the induction of the apoptosis. ET, EA, UA and UB showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells. This study suggests that the BRB seeds could be a potential source of anti-cancer ET.
Starting Page	1675
Ending Page	1683
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	5
Journal	Food & Function
DOI	10.1039/c5fo00274e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	UA EA UB Black people The Seeds Acid Urban area Large intestine Cancer Cell cycle G1 phase P21 Membrane potential Caspase Apoptosis
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Correction: Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells

Kynurenic acid enhances expression of p21 waf1/cip1 in colon cancer ht-29 cells.

Colon cancer ht-29 (2006).

Milk fat globule membrane isolate induces apoptosis in HT-29 human colon cancer cells

Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase.

Gold nanoparticles (AuNPs) and Rosmarinus officinalis extract and their potentials to prompt apoptosis and arrest cell cycle in HT-29 colon cancer cells

Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells.

Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.

Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells

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Correction: Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells

Kynurenic acid enhances expression of p21 waf1/cip1 in colon cancer ht-29 cells.

Colon cancer ht-29 (2006).

Milk fat globule membrane isolate induces apoptosis in HT-29 human colon cancer cells

Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase.

Gold nanoparticles (AuNPs) and Rosmarinus officinalis extract and their potentials to prompt apoptosis and arrest cell cycle in HT-29 colon cancer cells

Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells.

Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.

Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells