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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Li, Qian Liu, Chengmei Liu, Jiyan McClements, David Julian Zhai, Yuxin Chen, Jun Li, Ti |
| Copyright Year | 2015 |
| Abstract | Bioactive proanthocyanidins were isolated from the peel of Choerospondias axillaris fruit, which is a waste product of the food processing industry. Compositional analysis indicated that the proanthocyanidins had extension units mainly consisting of epicatechin gallate or epicatechin, and terminal units mainly consisting of catechin. Numerous polymeric forms of the molecules were detected, including monomers, dimers, and trimers. Certain fractions exhibited strong α-amylase or α-glucosidase inhibition in a dose-dependent manner. Furthermore, their inhibitory activities depended on their degree of polymerization and galloylation. For example, the most bioactive fraction had α-amylase and α-glucosidase inhibitory activities (IC50 values) of 541 and 3.1 μg mL−1, respectively. This study demonstrates that proanthocyanidins from C. axillaris peels can inhibit carbohydrate digestive enzymes in vitro and may therefore serve as antidiabetic ingredients in functional or medical foods. |
| Starting Page | 3693 |
| Ending Page | 3701 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 6 |
| Issue Number | 12 |
| Journal | Food & Function |
| DOI | 10.1039/c5fo00939a |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Choerospondias axillaris Gallic acid Catechin Alpha-amylase Glycoside hydrolase Polymerization IC50 Carbohydrate Anti-diabetic medication |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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