NDLI: Mechanistic evidence of <i>Passiflora edulis</i> (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed <i>via</i> LC-MS and chemometrics

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Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics

Content Provider	Royal Society of Chemistry (RSC)
Author	George, Camilia Farag, Mohamed A. Elsayed, Aly Otify, Asmaa
Copyright Year	2015
Abstract	Passiflora edulis Sims F. flavicarpa along with several other plants belonging to the genus Passiflora have been reported as sedatives and for treatment or prevention of central disorders. This study evaluated the anxiolytic effect of P. edulis ethanol extract and its fractions (viz. chloroform, ethyl acetate and butanol) using the elevated plus-maze model of anxiety and assessment of γ-aminobutyric acid levels. The results revealed that butanol and chloroform extracts exhibit the strongest effect followed by ethyl acetate suggesting that a combination of different classes of metabolites is likely to mediate for P. edulis anxiolytic effect in these fractions. To further pinpoint bioactive agents in fractions, ultra-performance liquid chromatography (UPLC) coupled to high resolution qTOF-MS was used for secondary metabolite profiling. A total of 65 metabolites were characterized including O-flavonoids, C-flavonoids, cyanogenic glycosides and fatty acids. Harman type alkaloids found in P. incarnata were not detected in P. edulis ethanol extract or any of its fractions suggesting that they do not mediate for its CNS modulating effects. Multivariate data analysis (PCA) was further applied to identify metabolite markers for fractions and revealed that enrichment of C-glycoside type flavonoids in chloroform/ethyl acetate fractions versus the exclusive presence of cyanogenic glycosides in its butanol fraction.
Starting Page	3807
Ending Page	3817
Page Count	11
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	6
Issue Number	12
Journal	Food & Function
DOI	10.1039/c5fo00875a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Sims Harman Passiflora Canna (plant) Genus Anxiolytic Ethanol Chloroform Ethyl acetate Butanol Anxiety Acid High-performance liquid chromatography Secondary metabolite Glycoside Passiflora incarnata Metabolite
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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