NDLI: Evaluation of hypocholesterolemic effect and antioxidant activity of <i>Boops boops</i> proteins in cholesterol-fed rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Jamoussi, Kamel Rebai, Tarek Barkia, Ahmed Lamri-Senhadji, Myriem Trigui, Mariem Kessis, Mondher Ghlissi, Zohra Sahnoun, Zouheir Boualga, Ahmed Lassoued, Imen Nasri, Moncef Nasri, Rim
Copyright Year	2014
Abstract	Dietary proteins affect blood cholesterol concentrations and antioxidant status, which are related to several diseases, including cardiovascular disease. The present study attempts to investigate the potential of Boops boops proteins (Bb-NHP) and its hydrolysate (Bb-HP) in the prevention of hypercholesterolemia and oxidative stress in rats fed a high cholesterol diet (HCD). After four weeks' treatment, serum lipid profiles (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol), the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the level of malonaldehyde (MDA) and the activities of antioxidant enzymes [catalase (CAT) and glutathione peroxidase (GPx)] in liver were determined. Compared with those fed a standard diet, high cholesterol diet induced dyslipidemia, oxidative stress, and aortic structure alterations. Interestingly, supplementing the HCD with Boops boops proteins attenuated these anomalies in a dose-dependent manner. These observations suggested that B. boops proteins might provide health benefits by helping to reduce the deleterious effects of increased intake of cholesterol that characterize modern diets.
Starting Page	1224
Ending Page	1231
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	6
Journal	Food & Function
DOI	10.1039/c3fo60705d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA Low-density lipoprotein Antioxidant Cardiovascular disease Bogue (fish) Hypercholesterolemia Oxidative stress Lipid Triglyceride Alanine transaminase Aspartate transaminase Catalase Glutathione peroxidase Liver Dyslipidemia Aorta
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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