NDLI: Phenolics extracted from tartary (<i>Fagopyrum tartaricum</i> L. Gaerth) buckwheat bran exhibit antioxidant activity, and an antiproliferative effect on human breast cancer MDA-MB-231 cells through the p38/MAP kinase pathway

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Phenolics extracted from tartary (Fagopyrum tartaricum L. Gaerth) buckwheat bran exhibit antioxidant activity, and an antiproliferative effect on human breast cancer MDA-MB-231 cells through the p38/MAP kinase pathway

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Phenolics extracted from tartary (Fagopyrum tartaricum L. Gaerth) buckwheat bran exhibit antioxidant activity, and an antiproliferative effect on human breast cancer MDA-MB-231 cells through the p38/MAP kinase pathway

Content Provider	Royal Society of Chemistry (RSC)
Author	Ming, Jian Li, Yao Zhang, Xiaoli Yin, Ran Li, Fuhua Lu, Keke
Copyright Year	2017
Abstract	Phenolics extracted from tartary buckwheat (Fagopyrum tartaricum L. Gaerth) bran were analyzed quantitatively and qualitatively. The bioactivity of the phenolic extracts was evaluated, such as the antioxidant activity, and the inhibition capacity on the growth of cancer cells. The molecular mechanism for the inhibitive effect on cancer cells was explored. Results indicated that tartary buckwheat bran phenolics mainly exist in a free form, and free phenolics were twice as abundant as bound phenolics. Free caffeic acid (119.75 μg per 100 mg DW) and bound rutin (51.66 μg per 100 mg DW) represented the main free and bound phenolic compounds, respectively. The free phenolic extract contributed to the major (>90%) antioxidant activities including the oxygen radical antioxidant capacity (ORAC) and cellular antioxidant activity (CAA). The free phenolic extract exhibited anticancer activity for human breast cancer MDA-MB-231 cells in a dose-dependent manner. This significant inhibition effect was achieved through the p38/MAP kinase pathway by inducing cell apoptosis (up-regulating p-p38 and p-ASK1 expressions and down-regulating TRAF2 and p-p53 expressions), and negatively regulating the progression of the cell cycle from the G1 to S phase (increased expression of p21 and suppressed expressions of PCNA, cyclin D1 and CDK4). All these results indicated that tartary buckwheat bran could be a rich resource of natural antioxidants and inhibitors for the growth of MDA-MB-231 cells.
Starting Page	177
Ending Page	188
Page Count	12
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	1
Journal	Food & Function
DOI	10.1039/c6fo01230b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	CAA Gaerth Tartary Buckwheat Fagopyrum Antioxidant Cancer Acid Rutin Oxygen Breast cancer List of breast cancer cell lines P38 mitogen-activated protein kinases Mitogen-activated protein kinase Apoptosis TRAF2 Cell cycle S phase P21 Proliferating cell nuclear antigen Cyclin D1 Cyclin-dependent kinase 4
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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The composition, antioxidant and antiproliferative capacities of phenolic compounds extracted from tartary buckwheat bran [Fagopyrum tartaricum (L.) Gaerth]

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Phenolics extracted from tartary (Fagopyrum tartaricum L. Gaerth) buckwheat bran exhibit antioxidant activity, and an antiproliferative effect on human breast cancer MDA-MB-231 cells through the p38/MAP kinase pathway

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The composition, antioxidant and antiproliferative capacities of phenolic compounds extracted from tartary buckwheat bran [Fagopyrum tartaricum (L.) Gaerth]

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