NDLI: Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

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Back cover

Food & Function Vol -7

Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

Content Provider	Royal Society of Chemistry (RSC)
Author	Domínguez-Avila, J. Abraham Velderrain-Rodríguez, Gustavo R. Wall-Medrano, Abraham Chen, C.-Y. Oliver Salazar-López, Norma Julieta Robles-Sánchez, Maribel González-Aguilar, Gustavo A.
Copyright Year	2017
Abstract	The positive health effects of phenolic compounds (PCs) have been extensively reported in the literature. An understanding of their bioaccessibility and bioavailability is essential for the elucidation of their health benefits. Before reaching circulation and exerting bioactions in target tissues, numerous interactions take place before and during digestion with either the plant or host's macromolecules that directly impact the organism and modulate their own bioaccessibility and bioavailability. The present work is focused on the gastrointestinal (GI) interactions that are relevant to the absorption and metabolism of PCs and how these interactions impact their pharmacokinetic profiles. Non-digestible cell wall components (fiber) interact intimately with PCs and delay their absorption in the small intestine, instead carrying them to the large intestine. PCs not bound to fiber interact with digestible nutrients in the bolus where they interfere with the digestion and absorption of proteins, carbohydrates, lipids, cholesterol, bile salts and micronutrients through the inhibition of digestive enzymes and enterocyte transporters and the disruption of micelle formation. PCs internalized by enterocytes may reach circulation (through transcellular or paracellular transport), be effluxed back into the lumen (P-glycoprotein, P-gp) or be metabolized by phase I and phase II enzymes. Some PCs can inhibit P-gp or phase I/II enzymes, which can potentially lead to drug–nutrient interactions. The absorption and pharmacokinetic parameters are modified by all of the interactions within the digestive tract and by the presence of other PCs. Undesirable interactions have promoted the development of nanotechnological approaches to promote the bioaccessibility, bioavailability, and bioefficacy of PCs.
Starting Page	15
Ending Page	38
Page Count	24
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	8
Issue Number	1
Journal	Food & Function
DOI	10.1039/c6fo01475e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Bioavailability Metabolism Pharmacokinetics Cell wall Drug interaction Small intestine Large intestine Cholesterol Bile acid Enterocyte Micelle Paracellular transport Thylakoid P-glycoprotein
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

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Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds