NDLI: The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone

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Food & Function Vol - 7 Issue - 8

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The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone

Content Provider	Royal Society of Chemistry (RSC)
Author	Sang, Yaqiu Zhang, Genyi Li, Wenzhu
Copyright Year	2016
Abstract	Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is widely present in cereals and agricultural products. The literature reports suggest that oxidative damage seems to be a key determinant of ZEA-induced toxicity, and the protective effect of resveratrol (RSV), an antioxidant phenolic compound, on ZEA-induced cytotoxicity to HEK293 cells was investigated. The experimental results showed that ZEA decreased cell viability in a dose dependent manner with an IC50 value of 80 μM, and induced an increase in intracellular reactive oxygen species (ROS) in HEK293 cells. A remarkable elevation of MDA and decreased activity of manganese superoxide dismutase (MnSOD) were also observed. A decrease in mitochondrial membrane potential (MMP), cell cycle arrest at the G0/G1 phase, and increased cell apoptosis indicate a mitochondria-mediated apoptosis. RSV (2 μM) pretreatment not only recovered the activity of MnSOD, but also improved ZEA-induced cytotoxicity evidenced by increased MMP and cell viability, and decreased ROS. Furthermore, RSV pretreatment substantially upregulated the expression of the SIRT1 gene by 6.8 fold, reduced the acetylation level of the forkhead transcription factor FOXO3a, and decreased the expression ratio of Bax/Bcl-2. All these results demonstrated that RSV exhibited significant protective effects on ZEA-induced cell damage, and this effect may be attributed to the upregulation of SIRT1 and activation of FOXO3a-mediated pathways to enhance the resistance of cells to oxidative stress induced by ZEA exposure.
Starting Page	3703
Ending Page	3715
Page Count	13
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	9
Journal	Food & Function
DOI	10.1039/c6fo00191b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA MMP Zearalenone Mycotoxin Determinant Resveratrol Antioxidant Cytotoxicity IC50 Reactive oxygen species Manganese Superoxide dismutase Membrane potential Cell cycle G1 phase Apoptosis Sirtuin 1 Gene Acetylation Transcription factor Bcl-2-associated X protein Bcl-2 Oxidative stress
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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