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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Miyashita, Kazuo Hosokawa, Masashi Uemura, Mariko Shiota, Makoto Yamauchi, Ippei Iwashima-Suzuki, Ai |
| Copyright Year | 2016 |
| Abstract | Purified milk sphingomyelin (SM) was obtained from lipid concentrated butter serum (LC-BS) by successive separations involving solvent fractionation, selective saponification, and silicic acid column chromatography. The SM obtained was given to obese/diabetic KK-Ay mice and wild-type C57BL/6J mice. SM supplementation significantly increased fecal lipids paralleled with a decrease in non-HDL cholesterol levels in the serum and neutral lipids and in cholesterol levels in the livers of KK-Ay mice. The reduction of liver lipid levels also resulted in a decrease in the total fatty acid content of the KK-Ay mice livers, while n-3 fatty acids derived from the conversion of α-linolenic acid (18:3n-3) increased due to SM supplementation. In contrast to the KK-Ay mice, little change in the serum and liver lipids was observed in wild-type C57BL/6J mice. The present study suggests that SM may be effective only in subjects with metabolic disorders. |
| Starting Page | 3854 |
| Ending Page | 3867 |
| Page Count | 14 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 7 |
| Issue Number | 9 |
| Journal | Food & Function |
| DOI | 10.1039/c6fo00274a |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Sphingomyelin Lipid Butter Solvent Saponification Acid Column chromatography Cholesterol Liver Fatty acid |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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