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DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)

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Back cover

Food & Function Vol - 7 Issue - 3

Food & Function Vol - 7 Issue - 2

Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)

Content Provider	Royal Society of Chemistry (RSC)
Author	Abellán, Ángel Cejuela-Anta, Roberto Gil-Izquierdo, Ángel Genieser, Hans-Gottfried Martínez-Sanz, José Miguel Medina, Sonia García-Flores, Libia Alejandra Ferreres, Federico
Copyright Year	2016
Abstract	In this study we analyzed whether our aronia–citrus juice (ACJ, the composition is based on a mixture of 95% citrus juice with 5% of Aronia melanocarpa juice), rich in polyphenols, and physical exercise had an effect on seven catabolites of DNA identified in plasma and on a urine isoprostane (8-iso-PGF2α). Sixteen elite triathletes on a controlled diet for triathlon training (45 days) were used in this clinical trial. Our results show a decrease in the 8-hydroxy-2′-deoxyguanosine concentration due to chronic physical exercise. The ACJ intake and physical exercise maintained the guanosine-3′,5′-cyclic monophosphate plasmatic concentrations and decreased the concentration of 8-hydroxyguanine as well as urinary values of 8-iso-PGF2α. Finally, we observed a significant increase in the 8-nitroguanosine levels in triathletes after ACJ intake, compared to the placebo stage. It is concluded that the combination of the intake of ACJ, rich in polyphenolic compounds, with adequate training was able to influence the plasmatic and urinary values of oxidative stress biomarkers. This suggests a positive effect on the oxidative damage and potential associations with DNA repair mechanisms.
Starting Page	2084
Ending Page	2093
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	4
Journal	Food & Function
DOI	10.1039/c6fo00252h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Citrus Aronia melanocarpa DNA Blood plasma Urine Isoprostane Triathlon 45 Days Clinical trial Deoxyguanosine Guanosine 8-Oxo-2'-deoxyguanosine Placebo Oxidative stress DNA repair
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)