NDLI: The fate of <sup>13</sup>C-labelled and non-labelled inulin predisposed to large bowel fermentation in rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Monro, John A. Stoklosinski, Halina M. Hedderley, Duncan Butts, Christine A. Tavendale, Michael H. Rosendale, Douglas Roy, Nicole C. Ansell, Juliet Paturi, Gunaranjan Herath, Thanuja D.
Copyright Year	2016
Abstract	The fate of stable-isotope 13C labelled and non-labelled inulin catabolism by the gut microbiota was assessed in a healthy rat model. Sprague–Dawley male rats were randomly assigned to diets containing either cellulose or inulin, and were fed these diets for 3 days. On day (d) 4, rats allocated to the inulin diet received 13C-labelled inulin. The rats were then fed the respective non-labelled diets (cellulose or inulin) until sampling (d4, d5, d6, d7, d10 and d11). Post feeding of 13C-labelled substrate, breath analysis showed that 13C-inulin cleared from the host within a period of 36 hours. Faecal 13C demonstrated the clearance of inulin from gut with a 13C excess reaching maximum at 24 hours (d5) and then declining gradually. There were greater variations in caecal organic acid concentrations from d4 to d6, with higher concentrations of acetic, butyric and propionic acids observed in the rats fed inulin compared to those fed cellulose. Inulin influenced caecal microbial glycosidase activity, increased colon crypt depth, and decreased the faecal output and polysaccharide content compared to the cellulose diet. In summary, the presence of inulin in the diet positively influenced large bowel microbial fermentation.
Starting Page	1825
Ending Page	1832
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	4
Journal	Food & Function
DOI	10.1039/c5fo01056j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dawley Sprague Inulin Catabolism Microbiota Cellulose 36 Hours (1965 film) Acid Propionic acid Glycoside hydrolase Large intestine Intestinal gland Polysaccharide Gastrointestinal tract Fermentation
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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