NDLI: Inhibitor or promoter? The performance of polysaccharides from <i>Ganoderma lucidum</i> on human tumor cells with different p53 statuses

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Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

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Food & Function Vol - 7 Issue - 3

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Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

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Food & Function Vol -1

Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Jun-ming Wang, Xiao-xia Ding, Zhong-yang Zhang, Jue Xia, Yong-mei Cui, Steve W. Li, Jian
Copyright Year	2016
Abstract	Polysaccharides from Ganoderma lucidum (GLPs) have been taken as effective supplements by both healthy people and cancer patients for many years. However, this short survey indicates that instead of inhibiting cancer cell growth, both submerge-cultured intracellular GLP and fruiting body GLP can stimulate the growth of human carcinoma cell lines lacking functional p53, such as HCT-116 p53−/−, Saos-2, H1299, HL-60, MDA-MB-157. Conversely, the two GLPs inhibit all other assayed cells with functional p53. These results could be an alert since mutational inactivation of the tumor suppressor protein p53 is the most frequent genetic alteration found in human tumors.
Starting Page	1872
Ending Page	1875
Page Count	4
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	4
Journal	Food & Function
DOI	10.1039/c5fo01628b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ganoderma Lingzhi mushroom Cancer Carcinoma P53 NCI-60 Protein
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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