NDLI: Involvement of miR-539-5p in the inhibition of <i>de novo</i> lipogenesis induced by resveratrol in white adipose tissue

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Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue

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Food & Function Vol - 7 Issue - 2

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Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue

Content Provider	Royal Society of Chemistry (RSC)
Author	Martínez, J. Alfredo Aguirre, Leixuri Fernández-Quintela, Alfredo Miranda, Jonatan Milagro, Fermín I. Eseberri, Itziar Garcia-Lacarte, Marcos Portillo, María P. Gracia, Ana
Copyright Year	2016
Abstract	The epigenetic mechanisms of action of resveratrol as an anti-obesity molecule have not been fully addressed so far. The aim of the present study was to assess changes produced by resveratrol in the microRNA (miRNA) profile in white adipose tissue (WAT) and to relate these changes to those induced in the expression of genes involved in triacylglycerol metabolism. Male Wistar rats were fed (6 weeks) an obesogenic diet: a control group and a group treated with resveratrol (30 mg kg−1 d−1). A miRNA microarray was carried out in perirenal adipose tissue. The overexpression of miR-539-5p and miR-1224-5p was performed in 3T3-L1 cells. Protein expression was analysed by western-blot and gene expression by qRT-PCR. Associations between variables were assessed by Pearson's correlations. The microarray showed that 3 miRNAs were decreased and 13 were increased after resveratrol treatment. Among those miRNAs increased, miR-129, miR-328-5p and miR-539-5p showed predicted target genes relevant for triacylglycerol metabolism in WAT (pparγ: peroxisome proliferator-activated receptor gamma, hsl: hormone sensitive lipase and sp1: SP1 transcription factor) in the miRWalk database. Moreover, the literature shows that miR-1224, another miRNA up-regulated by resveratrol, can also regulate sp1. Among the three targets, only SP1 showed a reduction in protein expression. Correlation and overexpression studies revealed that the decrease in SP1 protein expression was only associated with the increase of miR-539-5p. In addition, significant reductions in SREBP1 protein expression and fasn gene expression were found in resveratrol-treated rats. In conclusion, the up-regulation of miR-539-5p is involved in the inhibition of de novo lipogenesis induced by resveratrol in WAT.
Starting Page	1680
Ending Page	1688
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	3
Journal	Food & Function
DOI	10.1039/c5fo01090j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Pearson Epigenetics Resveratrol MicroRNA White adipose tissue Triglyceride Metabolism DNA microarray Adipose tissue Gene Real-time polymerase chain reaction Peroxisome proliferator-activated receptor gamma Peroxisome Estrogen receptor Hormone Lipase Sp1 transcription factor Transcription factor Protein Lipogenesis
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator–activated receptor γ (PPARγ) during adipocyte differentiation

Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator–activated receptor γ (PPARγ) during adipocyte differentiation

Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue

Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor α deficiency

RESEARCH Open Access Changes in white adipose tissue metabolism induced by resveratrol in rats

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Peroxisome proliferator-activated receptor-a ligands inhibit cardiac lipoprotein lipase activity

Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation

Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue

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