NDLI: Peroxisome proliferator-activated receptor-a ligands inhibit cardiac lipoprotein lipase activity

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Peroxisome proliferator-activated receptor-a ligands inhibit cardiac lipoprotein lipase activity

Content Provider	Semantic Scholar
Author	Carroll, Rogayah Severson, David L.
Copyright Year	2001
Abstract	Carroll, Rogayah, and David L. Severson. Peroxisome proliferator-activated receptor-a ligands inhibit cardiac lipoprotein lipase activity. Am J Physiol Heart Circ Physiol 281: H888–H894, 2001.—Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that regulate gene expression of lipoprotein lipase (LPL) in liver and adipose tissue. We examined the direct effect of PPAR-a ligands on LPL catalytic activity in cultured cardiomyocytes from adult rat heart. After overnight culture (16 h), 1 mM Wy-14643 and 10 mM BM-17.0744 decreased total cellular LPL activity to ;50% of control with no change in enzyme synthesis or mass; as a consequence, PPAR-a activation produced a significant decrease in LPL specific activity (mU/ng LPL protein). Wy-14643 and BM-17.0744 also reduced heparin-releasable LPL activity and mass in the culture medium. Inhibition of LPL activity by Wy-14643 did not reduce the ability of insulin plus dexamethasone to stimulate cellular and heparin-releasable LPL activities. A similar inhibitory effect on cellular and heparin-releasable LPL activity was observed when cardiomyocytes were cultured with 60 mM linoleic acid. In conclusion, two different PPAR-a ligands (Wy-14643 and BM-17.0744) inhibited cellular LPL activity in cultured cardiomyocytes by a posttranscriptional and posttranslational mechanism.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpheart.physiology.org/content/ajpheart/281/2/H888.full.pdf
Language	English
Access Restriction	Open
Subject Keyword	Adipose tissue BM 17.0744 Carroll Morgan (computer scientist) Circa Culture Media Dexamethasone Gene Expression Heart Diseases Heart failure Ligands Linoleic Acid Lipoproteins Myocytes, Cardiac Peroxisome Proliferator-Activated Receptors Peroxisome Proliferators Sinoatrial Node TRANSCRIPTION FACTOR Transcription (software) WY 14,643 enzyme activity heparin lipoprotein lipase activity
Content Type	Text
Resource Type	Article

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