NDLI: Keto analogue and amino acid supplementation and its effects on ammonemia and performance under thermoneutral conditions

Content Provider	Royal Society of Chemistry (RSC)
Author	Camerino, Saulo Rodrigo Alves e Silva Gouveia, Marcos Guilherme de Sousa França, Thássia Casado Lima Prado, Eduardo Seixas Cameron, L. C. Herculano, Edla de Azevedo Rodrigues, Daniela Souza Araújo Lima, Rafaela Carvalho Pereira
Copyright Year	2016
Abstract	Alterations of cerebral function, fatigue and disturbance in cognitive-motor performance can be caused by hyperammonemia and/or hot environmental conditions during exercise. Exercise-induced hyperammonemia can be reduced through supplementation with either amino acids or combined keto analogues and amino acids (KAAA) to improve exercise tolerance. In the present study, we evaluated KAAA supplementation on ammonia metabolism and cognitive-motor performance after high-intensity exercise under a low heat stress environment. Sixteen male cyclists received a ketogenic diet for 2 d and were divided into two groups, KAAA (KEx) or placebo (CEx) supplementation. The athletes performed a 2 h cycling session followed by a maximum test (MAX), and blood samples were obtained at rest and during exercise. Cognitive-motor tasks were performed before and after the protocol, and the exhaustion time was used to evaluate physical performance. The hydration status was also evaluated. The CEx group showed a significant increase (∼70%) in ammonia concentration at MAX, which did not change in the KEx group. The non-supplemented group showed a significant increase in uremia. Both the groups had a significant increase in blood urate concentrations at 120 min, and an early significant increase from 120 min was observed in the CEx group. There was no change in the glucose concentrations of the two groups. A significant increase in lactate was observed at the MAX moment in both groups. There was no significant difference in the exhaustion times between the groups. No changes were observed in the cognitive-motor tasks after the protocol. We suggest that KAAA supplementation decreases ammonia concentration during high-intensity exercise but does not affect physical or cognitive-motor performances under a low heat stress environment.
Starting Page	872
Ending Page	880
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	2
Journal	Food & Function
DOI	10.1039/c5fo01054c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	KAAA MAX Hyperammonemia Metabolism Ketogenic diet Placebo Cex (musician) Uremia Uric acid Glucose Lactic acid
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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