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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | de Almeida, Rosemeire Dantas Prado, Eduardo Seixas Llosa, Carlos Daniel Magalhães-Neto, Anibal Cameron, Luiz-Claudio |
| Description | Country affiliation: Brazil Author Affiliation: de Almeida RD ( Laboratory of Protein Biochemistry, Federal University of State of Rio de Janeiro, Av. Pasteur, 296, Urca, Rio de Janeiro, Brazil.) |
| Abstract | During exercise, ammonia levels are related to the appearance of both central and peripheral fatigue. Therefore, controlling the increase in ammonia levels is an important strategy in ameliorating the metabolic response to exercise and in improving athletic performance. Free amino acids can be used as substrates for ATP synthesis that produces ammonia as a side product. Keto analogues act in an opposite way, being used to synthesise amino acids whilst decreasing free ammonia in the blood. Adult male rats were divided into four groups based on receiving either keto analogues associated with amino acids (KAAA) or a placebo and resistance exercise or no exercise. There was an approximately 40% increase in ammonaemia due to KAAA supplementation in resting animals. Exercise increased ammonia levels twofold with respect to the control, with a smaller increase (about 20%) in ammonia levels due to exercise. Exercise itself causes a significant increase in blood urea levels (17%). However, KAAA reduced blood urea levels to 75% of the pre-exercise values. Blood urate levels increased 28% in the KAAA group, independent of exercise. Supplementation increased glucose levels by 10% compared with control animals. Exercise did not change glucose levels in either the control or supplemented groups. Exercise promoted a 57% increase in lactate levels in the control group. Supplementation promoted a twofold exercise-induced increase in blood lactate levels. The present results suggest that an acute supplementation of KAAA can decrease hyperammonaemia induced by exercise. |
| File Format | HTM / HTML |
| ISSN | 00071145 |
| Issue Number | 10 |
| Volume Number | 104 |
| e-ISSN | 14752662 |
| Journal | British Journal of Nutrition |
| Language | English |
| Publisher | Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date | 2010-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Discipline Sciences Amino Acids Pharmacology Keto Acids Chemistry Motor Activity Physiology Physical Conditioning, Animal Administration & Dosage Animal Feed Animal Nutritional Physiological Phenomena Animals Diet Dietary Supplements Hyperammonemia Lactic Acid Blood Male Rats Rats, Wistar Uric Acid Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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