NDLI: Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

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Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

Content Provider	Royal Society of Chemistry (RSC)
Author	Busse, Alexandre L. Cozzolino, Silvia M. F. Magaldi, Regina M. Cominetti, Cristiane Jacob-Filho, Wilson Hare, Dominic J. McColl, Gawain Cardoso, Bárbara R. Horst, Maria A.
Copyright Year	2016
Abstract	Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia. Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are both thought to involve impaired biological activity of certain selenoproteins. Previously, supplementation with a selenium-rich Brazil nut (Bertholletia excelsa) has shown potential in reducing cognitive decline in MCI patients, and could prove to be a safe and effective nutritional approach early in the disease process to slow decline. Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression. Our data suggest that GPX1 Pro198Leu rs1050450 genotypes may differentially affect the selenium status and GPx activity. Moreover, rs7579 and rs3877899 SNPs in SEPP gene, as well as GPX1 rs1050450 genotypes can influence the expression of GPX1 and SEPP mRNA in response to Brazil nuts intake. This small study gives cause for larger investigations into the role of these SNPs in both the selenium status and response to selenium dietary intake, especially in chronic degenerative conditions like MCI and AD.
Starting Page	825
Ending Page	833
Page Count	9
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	2
Journal	Food & Function
DOI	10.1039/c5fo01270h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	MCI Brazil Antioxidant Pathology Dementia Mild cognitive impairment Brazil nut Single-nucleotide polymorphism Glutathione peroxidase Selenoprotein Selenium Oxidative stress Gene Messenger RNA
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial

Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts.

Pro198Leu Polymorphism of GPx-1 Gene and Activity of Erythrocytic Glutathione Peroxidase and Lipid Peroxidation Products

Biomarkers of Selenium Status

Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians

Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson's Disease.

Case control feasibility study assessing the association between severity of coronary artery disease with Glutathione Peroxidase-1 (GPX-1) and GPX-1 polymorphism (Pro198Leu)

Selenium and Chronic Diseases: A Nutritional Genomics Perspective

The single-nucleotide polymorphism ( GPX 4 c 718 t ) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

Similar Documents

Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial

Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts.

Pro198Leu Polymorphism of GPx-1 Gene and Activity of Erythrocytic Glutathione Peroxidase and Lipid Peroxidation Products

Biomarkers of Selenium Status

Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians

Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson's Disease.

Case control feasibility study assessing the association between severity of coronary artery disease with Glutathione Peroxidase-1 (GPX-1) and GPX-1 polymorphism (Pro198Leu)

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The single-nucleotide polymorphism ( GPX 4 c 718 t ) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake