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Keto analogues and amino acid supplementation and its effects on ammonaemia during extenuating endurance exercise in ketogenic diet-fed rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ferreira, Rogério T. S. Gonçalves, Sandra Cunha Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio Bassini, Adriana Coelho, Wagner Santos Magalhães-Neto, Aníbal M. De Prado, Eduardo Silva Cameron, L. C. |
| Copyright Year | 2018 |
| Abstract | Keto analogues and amino acids (KAAA) supplementation can reduce blood ammonia concentrations in athletes undergoing high-intensity exercise under both ketogenic and thermoneutral conditions. This study evaluated the acute effects of KAAA supplementation on ammonia metabolism during extenuating endurance exercise in rats fed a ketogenic diet. In all, eighty male Fischer rats at 90 d of age were divided into eight groups, and some were trained using a swimming endurance protocol. A ketogenic diet supplemented with keto analogues was administered for 10 d. Administration of the ketogenic diet ended 3 d before the exhaustion test (extenuating endurance exercise). A ketogenic diet plus KAAA supplementation and extenuating endurance exercise (trained ketogenic diet supplemented with KAAA (TKKa)) increased blood ammonia concentrations by approximately 50 % compared with the control diet (trained control diet supplemented with KAAA (TCKa)) and similar training (effect size=1·33; statistical power=0·50). The KAAA supplementation reduced blood urea concentrations by 4 and 18 % in the control and ketogenic diet groups, respectively, compared with the groups fed the same diets without supplementation. The trained groups had 60 % lower blood urate concentrations after TCKa treatment than after TKKa treatment. Our results suggest that KAAA supplementation can reduce blood ammonia concentrations after extenuating endurance exercise in rats fed a balanced diet but not in rats fed a ketogenic diet. |
| Starting Page | 732 |
| Ending Page | 739 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1017/S0007114518001770 |
| PubMed reference number | 30079843 |
| Journal | Medline |
| Volume Number | 120 |
| Issue Number | 7 |
| Alternate Webpage(s) | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114518001770 |
| Alternate Webpage(s) | https://doi.org/10.1017/S0007114518001770 |
| Journal | The British journal of nutrition |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
