NDLI: Whole body radioprotective effect of phenolic extracts from the fruits of <i>Malus baccata</i> (Linn.) Borkh

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Whole body radioprotective effect of phenolic extracts from the fruits of Malus baccata (Linn.) Borkh

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Food & Function Vol -6

Food & Function Vol -5

Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Whole body radioprotective effect of phenolic extracts from the fruits of Malus baccata (Linn.) Borkh

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Xiaoyu Wang, Lu Wang, Zhenyu
Copyright Year	2016
Abstract	This study was designed to evaluate the radioprotective effect of phenolics extracted from the fruits of Malus baccata (Linn.) Borkh. (MBP-3b) against damage induced by 60Co γ-irradiation in vivo. MBP-3b could significantly improve the activity of endogenous antioxidant enzymes and the T-AOC, as well as reduce the MDA level in the liver and kidneys of irradiated mice. In addition, pretreatment with MBP-3b at a dose of 150 mg per kg bw could significantly enhance immunomodulation activity by promoting the proliferation of spenocytes and monocyte phagocytosis. The administration of MBP-3b prevented the decline induced by radiation of haematological parameters (WBC, RBC, PLT and HGB). Furthermore, MBP-3b could protect spenocytes from radiation-induced damage by inhibiting cell apoptosis. The results indicated that MBP-3b possesses strong whole body radioprotective and immunomodulatory activities. The main constituents of MBP-3b were tentatively identified as delphinidin-3,5-diglucoside, cyanidin-3-glucoside, chlorogenic acid, proanthocyanidin C1, quercetin-3-galactoside, quercetin-3-glucoside, quercetin-3-xyloside/arabinoside, phloretin-2-xyloseglucoside, quercetin-3-rhamnoside and phlorizin. MBP-3b could be used as a probable radioprotector against gamma radiation induced oxidative damage.
Starting Page	975
Ending Page	981
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	2
Journal	Food & Function
DOI	10.1039/c5fo01377a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA WBC RBC Linn Nuclear safety and security Malus baccata Linn Records Cobalt-60 Antioxidant Liver Immunotherapy Monocyte Phagocytosis White blood cell Apoptosis Delphinidin Chrysanthemin Acid Proanthocyanidin Quercetin Galactoside Glucoside Xyloside Arabinose Phloretin Rhamnose Gamma ray
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Phytochemical composition and antioxidant activity of Malus baccata (L.) Borkh. fruits

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Optimization of ultrasonic-assisted extraction of phenolic antioxidants from Malus baccata (Linn.) Borkh. using response surface methodology.

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MICROPROPAGATION OF CRAB APPLE (Malus baccata Borkh var. himalaica)

Whole body radioprotective effect of phenolic extracts from the fruits of Malus baccata (Linn.) Borkh

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