NDLI: A novel electrochemical sensor based on a silver nanoparticle modified carbon ionic liquid electrode for selective and sensitive determination of levetiracetam in pharmaceutical tablets and blood plasma samples

Content Provider	Royal Society of Chemistry (RSC)
Author	Karimi, Ziba Arkan, Elham Majnooni, Mohammadbagher Shamsipur, Mojtaba Saber, Reza
Copyright Year	2014
Abstract	An electrochemical sensor based on a silver nanoparticle (AgNP) modified carbon ionic liquid electrode (CILE) was prepared for the determination of ultra trace levels of levetiracetam (LEV) in human plasma and pharmaceutical tablets. The AgNPs were electrodeposited on the CILE surface using a double pulse potentiostatic technique, which can suitably control the size and morphology of AgNPs electrodeposited on the electrode. The AgNPs deposited on the CILE surface revealed an excellent electrocatalytic activity towards the oxidation of LEV. The sensor exhibited a fast response towards LEV with a linear concentration range of 1–300 ng mL−1 and a limit of detection of 0.7 ng mL−1. The possible interference from several common ions and drugs that usually accompany LEV was tested. The method was successfully applied to the determination of LEV content in real samples such as tablets and human plasma samples with good recovery, and the obtained results were checked by HPLC. The proposed sensor is suitable for routine analysis of LEV in plasma samples to monitor the therapeutic or toxic levels of LEV and for drug pharmacokinetic studies.
Starting Page	2197
Ending Page	2204
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	7
Journal	Analytical Methods
DOI	10.1039/c3ay42295j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Electrode Electrochemistry Electroplating High-performance liquid chromatography Pharmacokinetics Carbon Silver nanoparticle Ionic liquid Levetiracetam Blood plasma
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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