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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Abdouss, Majid Asadi, Ebadullah Ahmadi, Fardin Azodi-Deilami, Saman Najafabadi, Alireza Hassani Farzaneh, Sina |
| Copyright Year | 2015 |
| Abstract | In this study, a highly selective voltammetric sensor is introduced for the monitoring of meloxicam by using a new carbon paste electrode (CPE). A meloxicam molecularly imprinted polymer (MIP) and a non-imprinted polymer (NIP), polymerizing on the surface of functionalized multiwall carbon nanotubes (MWCNTs), were synthesized and then used for the preparation of carbon paste electrodes (CPEs) to improve the selectivity and conductivity of the prepared sensor. The sensor was applied for the determination of meloxicam using the cathodic stripping voltammetric method. The MIP@MWCNT–CP electrode showed higher recognition ability in comparison to the NIP@MWCNT–CP. Some parameters affecting the sensor response were optimized and then the calibration curve was plotted. Under optimized conditions, two linear dynamic ranges from 4.33 × 10−5 to 2.85 × 10−3 mg L−1 and 2.85 × 10−3 to 7.53 × 10−2 mg L−1 were obtained. The detection limit and quantitation limit of the sensor were calculated to be 3.22 × 10−5 and 1.1 × 10−4 mg L−1, respectively, which indicated the sensitivity of the proposed procedure. The proposed sensor is applied to determine meloxicam in plasma samples and the recovery results were found to be between 98.0 and 102.5% using the voltammetric method with acceptable precision of less than 3.1%. |
| Starting Page | 1280 |
| Ending Page | 1292 |
| Page Count | 13 |
| File Format | HTM / HTML PDF |
| ISSN | 17599660 |
| Volume Number | 7 |
| Issue Number | 4 |
| Journal | Analytical Methods |
| DOI | 10.1039/c4ay02034k |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Meloxicam Carbon nanotube Electrode Molecularly imprinted polymer CPE Polymer Carbon paste electrode Carbon Blood plasma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Engineering Chemical Engineering |
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