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Derivative spectrophotometric and micellar high performance liquid chromatographic methods for simultaneous determination of silymarin and dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) in raw materials and capsules

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Analytical Methods Vol - 6 Issue - 3

Analytical Methods Vol -5

Analytical Methods Vol -4

Analytical Methods Vol -3

Analytical Methods Vol -2

Analytical Methods Vol -1

Derivative spectrophotometric and micellar high performance liquid chromatographic methods for simultaneous determination of silymarin and dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) in raw materials and capsules

Content Provider	Royal Society of Chemistry (RSC)
Author	Abass, Samah Abo El Ibrahim, Fawzia Walash, Mohamed I.
Copyright Year	2014
Abstract	First derivative ultraviolet spectrophotometric and micellar high performance liquid chromatographic assay methods were developed and validated for the simultaneous determination of silymarin and dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) in the pure form and in combined capsules. The first derivative (D1) was performed by measuring the amplitudes at 279 and 255 nm for silymarin and DDB, respectively. The calibration graphs were linear in the range of 3–40 μg mL−1 for silymarin and 3–30 μg mL−1 for DDB. An isocratic reversed phase chromatographic assay method was also developed for the determination of both drugs, a C18 column (250 mm × 4.6 mm i.d., 5 μm particle size) was used with a mobile phase composed of 0.17 M sodium dodecyl sulphate, 12% butanol and 0.3% triethylamine, all prepared in 0.02 M phosphoric acid and adjusted to pH 3.5. The flow rate was 1 mL min−1. The effluents were monitored at 288 nm and floctafenine was used as the internal standard. Plots of the peak area ratios of each drug to floctafenine were found to be linear in the range of 1–15 μg mL−1 for silymarin and 1–12 μg mL−1 for DDB. The proposed methods were validated according to ICH guidelines. The methods were successfully applied in the estimation of silymarin and DDB in their combined capsules dosage form.
Starting Page	1158
Ending Page	1166
Page Count	9
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	4
Journal	Analytical Methods
DOI	10.1039/c3ay41934g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Acid DDB Lauric acid Micelle Floctafenine Ultraviolet Chromatography Sodium Silibinin Micrometre Triethylamine Derivative PH Dosage form Butanol Ferrari 250 Spectrophotometry
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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Metabolism of dimethyl-4,4-dimethoxy-5,6,5,6-dimethylene dioxybiphenyl-2,2-dicarboxylate (ddb) by human liver microsomes: characterization of metabolic pathways and of cytochrome p450 isoforms involved (2000).

Validated Optimized Method for Simultaneous Analysis of Active Silymarin Components and Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene Dioxybiphenyl-2,2′-dicarboxylate in a Pharmaceutical Preparation by Use of a Monolithic Silica C18 Column

Antitumor Agents. 293. Nontoxic Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) Analogues Chemosensitize Multidrug-Resistant Cancer Cells to Clinical Anticancer Drugs

A green HPLC method for the analysis and stability study of flavoxate HCl using micellar eluent

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Antitumor Agents 293. Non-toxic Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) Analogs Chemosensitize Multidrug Resistant Cancer Cells to Clinical Anticancer Drugs

A validated HPLC method for the determination of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) with fluorescence detection in raw material and pill form: application to an in vitro dissolution test and a content uniformity test.

Contribution of a significant first-pass effect of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in the liver to its poor bioavailability in rats.

Hydroxyanthraquinones and Their Micellar Aggregates as Spectrophotometric Reagents for Trace Analysis of Metal Ions

Derivative spectrophotometric and micellar high performance liquid chromatographic methods for simultaneous determination of silymarin and dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) in raw materials and capsules

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