NDLI: Analysis of <i>N</i>-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

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Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

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Analytical Methods Vol - 6 Issue - 3

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Analytical Methods Vol -1

Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

Content Provider	Royal Society of Chemistry (RSC)
Author	Stevenson, Richard Powell, Mark Page, Nathanael
Copyright Year	2014
Abstract	N-Methylpyrrolidine (NMP) is the principal hydrolysis product of cefepime hydrochloride, a β-lactam antibiotic. NMP is limited in cefepime hydrochloride by current regulations to not more than 0.3% w/w. Existing methods for the liquid-phase chromatographic analysis of this impurity fail to separate NMP from the drug substance prior to analysis, with the result that NMP continues to be formed by hydrolysis of cefepime in the final analytical solution. This study proposes a simple, rapid solid-phase extraction procedure that separates NMP from cefepime hydrochloride prior to analysis. NMP was separated from the majority of cefepime in the sample solution using polymeric reverse phase solid-phase extraction. Recovery, precision, sensitivity, linearity and specificity values were adequate to support the use of this method for regulatory purposes. The relative amount of NMP formed in sample extracts processed by solid-phase extraction was at least five times less compared to untreated samples.
Starting Page	1248
Ending Page	1253
Page Count	6
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	4
Journal	Analytical Methods
DOI	10.1039/c3ay42041h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	NMP Hydrolysis Solid phase extraction Cefepime Pyrrolidine Β-lactam antibiotic Chromatography
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

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Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

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